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World J Otorhinolaryngol. Aug 28, 2013; 3(3): 58-70
Published online Aug 28, 2013. doi: 10.5319/wjo.v3.i3.58
Published online Aug 28, 2013. doi: 10.5319/wjo.v3.i3.58
Noise-induced hearing loss in the 21st century: A research and translational update
Ann Chi Yan Wong, Kristina E Froud, Translational Neuroscience Facility, Department of Physiology, Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Yves Shang-Yi Hsieh, School of Chemistry, University of Sydney, Sydney, NSW 2052, Australia
Author contributions: All authors contributed equally to this work.
Correspondence to: Ann Chi Yan Wong, PhD, Translational Neuroscience Facility, Department of Physiology, Faculty of Medicine, School of Medical Sciences, University of New South Wales, UNSW, Sydney NSW 2052, Australia. acy.wong@unsw.edu.au
Telephone: +61-2-93852443 Fax: +61-2-93851485
Received: May 21, 2013
Revised: July 10, 2013
Accepted: July 17, 2013
Published online: August 28, 2013
Processing time: 108 Days and 0.7 Hours
Revised: July 10, 2013
Accepted: July 17, 2013
Published online: August 28, 2013
Processing time: 108 Days and 0.7 Hours
Core Tip
Core tip: Noise-induced hearing loss (NIHL) affects millions of people worldwide irrespective of age, sex, and race. Hearing aids and cochlear implants are currently the only available interventions. This review article summarizes the cellular and molecular mechanisms of NIHL to-date. Significant milestones in uncovering genetic predisposition to NIHL in humans, experimental gene therapies and post-noise otoprotective strategies to reduce the impact of NIHL are reviewed.