Microglandular hyperplasia-like mucinous adenocarcinoma of the endometrium: A rare case report

Figure 1 Microglandular hyperplasia-like pattern in dilatation and curettage, hematoxylin-eosin staining. A: Complex microglandular proliferation of small back-to-back glands, without intervening stroma, with mucin production and accumulation of neutrophils in the gland lumen and stroma (× 10); B: Rare area where Microglandular hyperplasia-like adenocarcinoma (on the right) is merging with more conventional endometrioid adenocarcinoma (on the left) (× 20); C: Endometrioid adenocarcinoma area shows pseudostratification, mild atypia and rare mitoses (× 40).

Figure 2 Immunohistochemical staining. A: Immunohistochemical stain for VIM shows positive stain in the microglandular hyperplasia-like adenocarcinoma (MGA) in the curettage specimen (× 10); B: Immunohistochemical stain for CEA shows positive stain in the MGA in the curettage specimen (× 10); C: Immunohistochemical stain shows positive expression for p16 in the MGA in the curettage specimen (× 10).

Figure 3 Macroscopic appearance of the uterus. There are obvious the leiomyoma, the cervical polyp and the flat appearance of the endometrial area.

Figure 4 Hysterectomy specimen. A: Residual carcinoma of conventional mucinous type in the hysterectomy specimen (× 20); B: Areas of ciliated and small non-villous papillae in the residual adenocarcinoma of the endometrium in the hysterectomy specimen (× 20); C: Adenocarcinoma with microglandular hyperplasia (MGH)-like pattern occurs on the tumor surface of conventional adenocarcinoma in a plaque-like fashion (× 10); D: Higher magnification of C (× 20); E: Adenocarcinoma with MGH-like pattern occurs on the tumor surface of conventional adenocarcinoma (another area) (× 40).