Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Obstet Gynecol. Nov 10, 2015; 4(4): 72-76
Published online Nov 10, 2015. doi: 10.5317/wjog.v4.i4.72
Published online Nov 10, 2015. doi: 10.5317/wjog.v4.i4.72
Infertility and ovarian failure in celiac disease
Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver V6T 1W5, Canada
Author contributions: Freeman HJ contributed all to this paper.
Conflict-of-interest statement: Freeman HJ declares no conflict of interest or potential conflict of interest related to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hugh James Freeman, MD, CM, FRCPC, FACP, Department of Medicine (Gastroenterology), University of British Columbia, 2211 Wesbrook, Mall, Vancouver V6T 1W5, Canada. hugfree@shaw.ca
Telephone: +1-604-8227216 Fax: +1-604-822236
Received: April 7, 2015
Peer-review started: April 9, 2015
First decision: June 3, 2015
Revised: June 10, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: November 10, 2015
Peer-review started: April 9, 2015
First decision: June 3, 2015
Revised: June 10, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: November 10, 2015
Core Tip
Core tip: Females with unexplained infertility should be screened for celiac disease. This involves use of a simple and inexpensive serological quantitative method for detection of tissue transglutaminase antibodies, a marker for celiac disease. If positive, biopsy evaluation should be done to determine if pathological features of untreated celiac disease are present in the small intestinal mucosa. A gluten-free diet may lead to effective management of celiac disease and may promote a favorable pregnancy outcome.