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World J Obstet Gynecol. Nov 10, 2013; 2(4): 153-166
Published online Nov 10, 2013. doi: 10.5317/wjog.v2.i4.153
Neoadjuvant chemotherapy and cytoreductive surgery in epithelial ovarian cancer
Siriwan Tangjitgamol, Jitti Hanprasertpong, Marta Cubelli, Claudio Zamagni
Siriwan Tangjitgamol, Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, University of Bangkok Metropolis, Bangkok 10300, Thailand
Jitti Hanprasertpong, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
Marta Cubelli, Claudio Zamagni, Medical Oncology Unit, Addarii Institute of Oncology, Policlinico S. Orsola-Malpighi University Hospital, 40100 Bologna, Italy
Author contributions: Tangjitgamol S, Hanprasertpong J, Cubelli M and Claudio Z outlined the topics of discussion, performed literature review, wrote portions of the initial draft, reviewed and revised the subsequent drafts, and compiled the final manuscript; all authors reviewed, revised, compiled the manuscript, and approved the final manuscript.
Correspondence to: Siriwan Tangjitgamol, MD, Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, University of Bangkok Metropolis, 681 Samsen Road, Dusit, Bangkok 10300, Thailand. siriwanonco@yahoo.com
Telephone: +66-2-2433666 Fax: +66-2-2437907
Received: December 13, 2012
Revised: January 13, 2013
Accepted: February 5, 2013
Published online: November 10, 2013
Processing time: 339 Days and 9.1 Hours
Core Tip

Core tip: Neoadjuvant chemotherapy (NACT) is an option when the primary surgery is expected to be impossible or suboptimal, or when high morbidity is anticipated. Delayed primary surgery or interval debulking surgery (IDS) is performed in patients who show some clinical response to neoadjuvant or induction chemotherapy. Preoperative clinical data to predict surgical outcomes and selection criteria for primary surgery followed by adjuvant chemotherapy or for NACT followed by IDS will be discussed in this chapter.