Zhang XQ, Zhang LJ, Yang WH, Draper ML. Effect of the maternal-fetal interface immunoregulation on the occurrence of intrahepatic cholestasis of pregnancy. World J Obstet Gynecol 2015; 4(2): 40-45 [DOI: 10.5317/wjog.v4.i2.40]
Corresponding Author of This Article
Xiu Quan Zhang, MD, PhD, Department of Obstetrics and Gynecology, University of Utah School of Medicine, 50 N Medical Dr., Salt Lake City, UT 84132, United States. xiuquan.zhang@hsc.utah.edu
Research Domain of This Article
Immunology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Obstet Gynecol. May 10, 2015; 4(2): 40-45 Published online May 10, 2015. doi: 10.5317/wjog.v4.i2.40
Effect of the maternal-fetal interface immunoregulation on the occurrence of intrahepatic cholestasis of pregnancy
Xiu Quan Zhang, Li-Juan Zhang, Wei-Hong Yang, Michael L Draper
Xiu Quan Zhang, Michael L Draper, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 84132, United States
Li-Juan Zhang, Wei-Hong Yang, Department of Obstetrics and Gynecology, Xiangya Second Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Zhang XQ, Zhang LJ, Yang WH and Draper ML contributed to this paper.
Conflict-of-interest: Authors have no conflict of interest for this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiu Quan Zhang, MD, PhD, Department of Obstetrics and Gynecology, University of Utah School of Medicine, 50 N Medical Dr., Salt Lake City, UT 84132, United States. xiuquan.zhang@hsc.utah.edu
Telephone: +1-801-5813117 Fax: +1-801-5858552
Received: October 27, 2014 Peer-review started: October 27, 2014 First decision: December 12, 2014 Revised: January 14, 2015 Accepted: January 30, 2015 Article in press: February 2, 2015 Published online: May 10, 2015 Processing time: 185 Days and 8.2 Hours
Abstract
Maternal immune tolerance of the fetus is indispensable for a healthy pregnancy. Currently, the study of the immune microenvironment of the maternal-fetal interface has been a heated topic in reproductive immunology research. More and more studies show that the immune imbalance in the maternal-fetal interface plays a very important role in the incidence of intrahepatic cholestasis of pregnancy (ICP). However, the precise etiology and mechanism of immune imbalance in the occurrence of ICP is still unknown. In order to clarify the potential immunologic mechanisms of ICP, this review summarizes the recent studies of the decidual immunology microenvironment and the potential immunologic mechanisms related to the development of ICP.
Core tip: In this paper, we reviewed the recent publications regarding the role of immunological interactions at the maternal-fetal interface on the occurrence of intrahepatic cholestasis. The literature shows that the decidual immunological microenvironment may relate to the development of intrahepatic cholestasis of pregnancy. Any approach that modulates immune tolerance at the maternal-fetal interface toward the natural state could provide insight in the treatment of intrahepatic cholestasis of pregnancy.
