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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Thrombolysis for mild stroke
Hai-Chao Ji, Le-Tian Yang, Fu-Ling Yan, Department of Neurology, Zhongda Hospital affiliated to Southeast University, Nanjing 210009, Jiangsu Province, China
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: None declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fu-Ling Yan, Professor, Department of Neurology, Zhongda Hospital affiliated to Southeast University, 87 Dingjia Qiao, Nanjing Hunan Road, Nanjing 210009, Jiangsu Province, China. yanfuling218@163.com
Telephone: +86-25-83262251 Fax: +86-25-83272011
Received: December 27, 2014
Peer-review started: December 29, 2014
First decision: January 20, 2015
Revised: April 3, 2015
Accepted: June 1, 2015
Article in press: June 2, 2015
Published online: June 28, 2015
Processing time: 192 Days and 13.3 Hours
Peer-review started: December 29, 2014
First decision: January 20, 2015
Revised: April 3, 2015
Accepted: June 1, 2015
Article in press: June 2, 2015
Published online: June 28, 2015
Processing time: 192 Days and 13.3 Hours
Core Tip
Core tip: Clinically, mild stroke patients are routinely excluded from thrombolysis, for the considering that they are too mild and expected to have a good outcome even left untreated. Recent studies showed that mild strokes might also benefit from thrombolysis. However, unlike major stroke, about two thirds of mild stroke patients will have good outcome in nature course; about the one third will end with poor outcomes but they are found to be mostly characterized by imaging features. So we proposed that neuroimaging-based approaches to define mid stroke and selecting mild stroke patients to thrombolysis may be future directions.