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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Neurol. Dec 28, 2013; 3(4): 138-143
Published online Dec 28, 2013. doi: 10.5316/wjn.v3.i4.138
Published online Dec 28, 2013. doi: 10.5316/wjn.v3.i4.138
Neuritin: A therapeutic candidate for promoting axonal regeneration
Tadayuki Shimada, Hiroko Sugiura, Kanato Yamagata, Neural Plasticity Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Author contributions: All the authors contributed to the writing and editing of all aspects of this mini-review.
Supported by JSPS KAKENHI partly, No. 24700349, No. 24659093, No. 25293239; and MEXT KAKENHI, No. 25110737
Correspondence to: Kanato Yamagata, MD, Neural Plasticity Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. yamagata-kn@igakuken.or.jp
Telephone: +81-3-68342358 Fax: +81-3-53163150
Received: June 19, 2013
Revised: August 19, 2013
Accepted: September 14, 2013
Published online: December 28, 2013
Processing time: 202 Days and 1.9 Hours
Revised: August 19, 2013
Accepted: September 14, 2013
Published online: December 28, 2013
Processing time: 202 Days and 1.9 Hours
Core Tip
Core tip: Neuritin has been shown to be an activity-regulated protein in neurons. Its expression also increases after neuronal damage. Neuritin induces neuritogenesis, arborization, and axonal elongation. These functions may be beneficial for axonal regeneration after nerve injury. Here, we review neuritin as a therapeutic candidate for promoting axonal regeneration in the peripheral and central nervous systems. We also discuss the possible involvement of neuritin in mossy fiber sprouting after epileptic seizures or brain ischemia.