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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
Low grade spinal malignant triton tumor with mature skeletal muscle differentiation
Ming Zhang, Jasvir S Khurana, Abir L Mukherjee, Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA 19140, United States
Michael Weaver, Department of Neurosurgery, Temple University Hospital, Philadelphia, PA 19140, United States
Author contributions: Zhang M carried out the case study design and manuscript draft; Weaver M provided the clinical and radiological information; Khurana JS participated in the diagnosis of the case and the manuscript review; Mukherjee AL conceived of the study, and participated in its design and coordination and finalized the manuscript; all authors read and approved the final manuscript.
Correspondence to: Abir L Mukherjee, MD, Department of Pathology and Laboratory Medicine, Temple University Hospital, 3401 N Broad Street, 2nd floor, Outpatient Building, Philadelphia, PA 19140, United States. abir.mukherjee@tuhs.temple.edu
Telephone: +1-215-7072412 Fax: +1-215-7073389
Received: May 21, 2013
Revised: August 22, 2013
Accepted: August 28, 2013
Published online: September 28, 2013
Processing time: 189 Days and 16 Hours
Revised: August 22, 2013
Accepted: August 28, 2013
Published online: September 28, 2013
Processing time: 189 Days and 16 Hours
Core Tip
Core tip: Malignant peripheral nerve sheath tumor (MPNST) is an uncommon sarcoma with dismal prognosis. Low grade MPNST with skeletal muscle differentiation (malignant triton tumor) in cervical spine is vanishingly rare. The present case is remarkable because of its rare location, low grade histological features and unusual immunophenotype of the mature skeletal muscle component, which were not previously described. Thus, our study expands the morphological spectrum and the clinicopathological significance of this uncommon tumor. These novel findings should be interesting to the neuropathologists, neurologists and neurosurgeons.