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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Hematol. Aug 6, 2014; 3(3): 115-117
Published online Aug 6, 2014. doi: 10.5315/wjh.v3.i3.115
Published online Aug 6, 2014. doi: 10.5315/wjh.v3.i3.115
Unusual cytogenetic abnormalities associated with Philadelphia chromosome
Sanjeev Kumar Sharma, Anil Handoo, Dharma Choudhary, Nitin Gupta, Department of Hemato-oncology and Bone Marrow Transplant, BL Kapur Superspeciality Hospital, New Delhi-05, India
Author contributions: Sharma SK designed and wrote the paper; Handoo A provided the laboratory data; Choudhary D and Gupta N provided the clinical data.
Correspondence to: Sanjeev Kumar Sharma, MD, DM, Department of Hemato-oncology and Bone Marrow Transplant, BL Kapur Superspeciality Hospital, Pusa Road, New Delhi-05, India. sksanjeev13@yahoo.com
Telephone: +91-996-8756303 Fax: +91-996-8756303
Received: December 25, 2013
Revised: February 8, 2014
Accepted: July 12, 2014
Published online: August 6, 2014
Processing time: 298 Days and 12.3 Hours
Revised: February 8, 2014
Accepted: July 12, 2014
Published online: August 6, 2014
Processing time: 298 Days and 12.3 Hours
Core Tip
Core tip: Cytogenetic abnormalities are the hallmark of leukemias. We report here two cases of unusual cytogenetic abnormalities associated with Philadelphia chromosome, one with mixed phenotypic acute leukemia showing monosomy 7 and t(9;22) (q34;q11.2) and the other with chronic myeloid leukemia and additional translocation involving chromosomes 10 and 13. Both patients achieved complete remission following imatinib based treatment.These two cases highlight the novel additional cytogenetic abnormalities associated with Ph chromosome.