Gao Q, Xin XW, Zhao C, Wang YJ, Wang W, Yin Y, Wang XR, Jin YP. Efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: A case report. World J Hematol 2022; 9(1): 6-12 [DOI: 10.5315/wjh.v9.i1.6]
Corresponding Author of This Article
You-Peng Jin, PhD, Chief Doctor, Pediatric Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China. jinyp79@sina.cn
Research Domain of This Article
Hematology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hematol. Feb 25, 2022; 9(1): 6-12 Published online Feb 25, 2022. doi: 10.5315/wjh.v9.i1.6
Efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: A case report
Qian Gao, Xiao-Wei Xin, Chun Zhao, Yu-Juan Wang, Wei Wang, Yi Yin, Xiao-Ru Wang, You-Peng Jin
Qian Gao, You-Peng Jin, Pediatric Intensive Care Unit, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong Province, China
Xiao-Wei Xin, Chun Zhao, Yu-Juan Wang, Wei Wang, Yi Yin, Xiao-Ru Wang, You-Peng Jin, Pediatric Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Author contributions: Material preparation and data collection were performed by Jin YP and Gao Q; the first draft of the manuscript was written by Gao Q; all authors read and approved the final manuscript; all authors contributed to the case report conception and design.
Supported byClinical Science and Technology Innovation Scheme of Jinan Province, No. 202019177 and No. 201704071.
Informed consent statement: Informed written consent was obtained from the patient’ parents for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: You-Peng Jin, PhD, Chief Doctor, Pediatric Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China. jinyp79@sina.cn
Received: September 29, 2021 Peer-review started: September 29, 2021 First decision: December 2, 2021 Revised: December 9, 2021 Accepted: February 12, 2022 Article in press: February 12, 2022 Published online: February 25, 2022 Processing time: 146 Days and 23 Hours
Abstract
BACKGROUND
Hemophagocytic lymphohistiocytosis (HLH) is a severe and potentially deadly condition associated with extensive inflammation and immune activation. Cytokine adsorption may serve as a supportive treatment that can stabilize organ function in affected patients by reducing their circulating cytokines levels. To date, no descriptions of clinical experiences associated with the use of HA330-II column hemoadsorption for the treatment of children affected by HLH have been published.
CASE SUMMARY
We describe the case of an 11-year-old child with Epstein-Barr virus-associated HLH complicated by liver failure. She underwent HA330-II column hemoadsorption and chemotherapy and exhibited reductions in levels of inflammatory cytokines, including interleukin (IL), IL-6, IL-8, IL-10, and interferon-γ. The patient’s condition and laboratory parameters gradually improved with treatment.
CONCLUSION
Hemoadsorption may play an important role in cytokine storm elimination in children with HLH combined with liver failure and consequent multiple organ failure.
Core Tip: Hemophagocytic hymphohistiocytosis (HLH) is an often fatal disease. We report an 11-year-old female who was diagnosed with Epstein-Barr virus-HLH and presented with coagulation disorders, liver damage, and respiratory insufficiency. In the present case, initially elevated interleukin (IL)-6, IL-8, IL-10, and interferon-γ levels were reduced to within normal ranges following hemoadsorption with HA330-II, and the patient’s condition gradually improved. HA330-II hemoadsorption has the ability to bridge the patient until chemotherapy can contribute to reduced HLH disease activity.
