Carbone A, Formisano T, Natale F, Cappelli Bigazzi M, Tartaglione D, Golia E, Gragnano F, Crisci M, Bianchi RM, Calabrò R, Russo MG, Calabrò P. Management of unstable angina in a patient with Haemophilia A. World J Hematol 2017; 6(2): 28-31 [DOI: 10.5315/wjh.v6.i2.28]
Corresponding Author of This Article
Paolo Calabrò, MD, PhD, FESC, Associate Professor, Chair of Cardiology, Second University of Naples, AORN dei Colli, Monaldi Hospital, Via Leonardo Bianchi n°1, 80131 Naples, Italy. paolo.calabro@unina2.it
Research Domain of This Article
Hematology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hematol. May 6, 2017; 6(2): 28-31 Published online May 6, 2017. doi: 10.5315/wjh.v6.i2.28
Management of unstable angina in a patient with Haemophilia A
Andreina Carbone, Tiziana Formisano, Francesco Natale, Maurizio Cappelli Bigazzi, Donato Tartaglione, Enrica Golia, Felice Gragnano, Mario Crisci, Renato Maria Bianchi, Raffaele Calabrò, Maria Giovanna Russo, Paolo Calabrò
Andreina Carbone, Tiziana Formisano, Francesco Natale, Maurizio Cappelli Bigazzi, Donato Tartaglione, Enrica Golia, Felice Gragnano, Mario Crisci, Renato Maria Bianchi, Raffaele Calabrò, Maria Giovanna Russo, Paolo Calabrò, Chair of Cardiology, Second University of Naples, AORN dei Colli, Monaldi Hospital, 80131 Naples, Italy
Author contributions: Carbone A, Formisano T, Natale F, Tartaglione D, Golia E and Gragnano F designed the report; Cappelli Bigazzi M and Crisci M performed clinical evaluation and interventional procedure; Gragnano F and Bianchi RM collected the patient’s data; Carbone A, Calabrò R, Russo MG and Calabrò P analyzed data and wrote the paper.
Institutional review board statement: This case report was exempt from the Institutional Review Board standards at Second University of Naples.
Informed consent statement: I declare that the patient gave his informed consent verbally, for the publication of the case report “Management of unstable angina in a patient with Haemophilia A”.
Conflict-of-interest statement: None conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Paolo Calabrò, MD, PhD, FESC, Associate Professor, Chair of Cardiology, Second University of Naples, AORN dei Colli, Monaldi Hospital, Via Leonardo Bianchi n°1, 80131 Naples, Italy. paolo.calabro@unina2.it
Telephone: +39-081-7065185
Received: November 11, 2016 Peer-review started: November 13, 2016 First decision: March 7, 2017 Revised: March 15, 2017 Accepted: April 4, 2017 Article in press: April 7, 2017 Published online: May 6, 2017 Processing time: 147 Days and 15.5 Hours
Abstract
Hemophilia A is an X-linked recessive disorder characterized by a deficiency of coagulation factor VIII (FVIII) and therefore by a greater risk of bleeding during percutaneous interventional procedures and during the dual antiplatelet therapy (DAPT) in patients with ischemic heart disease. Information regarding safe percutaneous procedures in hemophiliacs is limited. Since the introduction of FVVIII concentrates, the life expectancy of hemophiliac patients has improved and consequently, the rate of ischemic heart disease in this population is increased. Frequently the replacement therapy can trigger the onset of an acute coronary syndrome. We report a case of a patient with mild Hemophilia A, who presents with unstable angina, treated successfully with coronary angioplasty and drug eluting stent implantation without replacement of FVVIII, treated with long term DAPT without major bleeding after six months of follow up.
Core tip: Hemophilia is a rare condition, but in some cases, could create difficulties in the management of other disease, such as acute coronary syndrome and unstable angina. Data in literature regarding this condition are lacking. This case report would be an example of the management of patients with mild deficit of Factor VIII activity according to the recent consensus.
