Tuono De Manfouo R, Louokdom JS, Chetcha BC, Bakam Magoua LM, Nya PCB, Pieme CA, Tayou Tagny C. Involvement of haptoglobin in disease development. World J Hematol 2024; 11(2): 94171 [DOI: 10.5315/wjh.v11.i2.94171]
Corresponding Author of This Article
Romaric Tuono De Manfouo, MSc, Research Fellow, Department of Microbiology, Parasitology, Hematology, and Infectious Diseases, Hematology Unit, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé 296, Cameroon. romatuono@yahoo.fr
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hematol. Jul 9, 2024; 11(2): 94171 Published online Jul 9, 2024. doi: 10.5315/wjh.v11.i2.94171
Involvement of haptoglobin in disease development
Romaric Tuono De Manfouo, Josué Simo Louokdom, Bernard Claude Chetcha, Larissa Michelle Bakam Magoua, Prosper Cabral Biapa Nya, Constant Anatole Pieme, Claude Tayou Tagny
Romaric Tuono De Manfouo, Bernard Claude Chetcha, Claude Tayou Tagny, Department of Microbiology, Parasitology, Hematology, and Infectious Diseases, Hematology Unit, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé 296, Cameroon
Josué Simo Louokdom, Higher Institute of Health Sciences, Université des Montagnes, Bangangté 296, Cameroon
Larissa Michelle Bakam Magoua, Public Health and Biotechnology Research Laboratory (LAPHER-Biotech), Faculty of Sciences, University of Yaoundé 1, Yaoundé 296, Cameroon
Prosper Cabral Biapa Nya, Faculty of Sciences, Université de Dschang, Dschang 296, Cameroon
Constant Anatole Pieme, Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé 296, Cameroon
Author contributions: Tuono De Manfouo R conducted item retention, study design, and major contribution to manuscript writing; Bakam Magoua LM, Chetcha BC, Louokdom JS, Nya PCB, Pieme CA, and Tayou Tagny C contributed to manuscript writing and correction; All authors read and approved the final version of the manuscript, and all authors had full access to all of the data in this study and took complete responsibility for the integrity of the data and the accuracy of the data analysis; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Romaric Tuono De Manfouo, MSc, Research Fellow, Department of Microbiology, Parasitology, Hematology, and Infectious Diseases, Hematology Unit, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé 296, Cameroon. romatuono@yahoo.fr
Received: March 12, 2024 Revised: May 28, 2024 Accepted: June 20, 2024 Published online: July 9, 2024 Processing time: 114 Days and 9.5 Hours
Abstract
Haptoglobin (HP) is a liver glycoprotein that is actively synthesized during inflammatory and hemolytic processes. It also has pro-oxidant and proinflammatory properties, which are a function of its genotype. The genetic polymorphism of the chains leads to synthesis of three phenotypes/proteins, which are related to the number and type of chains and their molecular weight, namely HP1-1, HP1-2 and HP2-2. Patients with HP2-2 have more vascular complications, while those with HP1-1 have fewer. HP is involved in the worsening of diseases, such as HP2-2 in aggravation of vaso-occlusive crises in sickle cell disease, and worsening of the pathophysiology of other diseases. In contrast, HP1-1 confers better protection against diseases. All of this suggests that further studies should be conducted, including experimental and analytical studies focused on demonstrating the influence of different HP genotypes on individual clinical and hematological data. This would help in understanding the role played by this genetic polymorphism in the pathophysiology of diseases.
Core Tip: Haptoglobin (HP) is a serum glycoprotein of hepatocytic origin synthesized during the acute phase of inflammation. Its synthesis is thought to have proinflammatory, anti-inflammatory, pro-oxidative and antioxidant activities, depending on the genotype of HP present in the individual. There are three main forms of HP, 2-2, 2-1 and 1-1. HP2-2 is associated with worsening of disease, while HP1-1 is more likely to have a protective effect. Thus, it is important to identify HP genotype for prognostic prediction and prevention of some diseases.
