Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Atopic eczema treatment now and in the future: Targeting the skin barrier and key immune mechanisms in human skin
David C Bell, Sara J Brown, Skin Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
Author contributions: Bell DC performed the majority of the writing and produced the figures and table with advice from Brown SJ; Brown SJ edited and supplemented the text and provided advice in the development of the figures and table.
Conflict-of-interest statement: Bell DC has no conflict of interest to declare; Brown SJ receives funding from the Wellcome Trust (Senior Research Fellowship in Clinic Science reference 106865/Z/15/Z); she provides consultancy advice for CXR Biosciences.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sara J Brown, Professor of Molecular and Genetic Dermatology, Wellcome Trust Senior Research Fellow in Clinical Science, Honorary Consultant Dermatologist, Skin Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, James Arrott Drive, Dundee DD1 9SY, Scotland, United Kingdom. s.j.brown@dundee.ac.uk
Telephone: +44-1382-383210
Received: February 15, 2017
Peer-review started: February 15, 2017
First decision: March 7, 2017
Revised: March 14, 2017
Accepted: April 4, 2017
Article in press: April 5, 2017
Published online: August 2, 2017
Peer-review started: February 15, 2017
First decision: March 7, 2017
Revised: March 14, 2017
Accepted: April 4, 2017
Article in press: April 5, 2017
Published online: August 2, 2017
Core Tip
Core tip: Atopic eczema (atopic dermatitis) is an itchy inflammatory skin disease with complex aetiology, including impairment in barrier function and concomitant inflammation. Increased understanding of the molecular mechanisms in eczema pathogenesis has opened up opportunities for new therapeutic targets. This review summaries current understanding and highlights some novel treatments in development.