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©The Author(s) 2014. Published by Baishideng Publishing Group Inc. All rights reserved.
Specificity in the alteration of lesional and non-lesional skin lipids in atopic dogs
Iuliana Popa, UMR CNRS 8612, Faculty of Pharmacy, University Paris Sud XI, 92290 Chatenay-Malabry, France
Jacques Portoukalian, Marek Haftek, University of Lyon-1, Laboratory of Dermatological Research EA 4169, 69008 Lyon, France
Author contributions: All authors equally contributed to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Iuliana Popa, Associate Professor, UMR CNRS 8612, Faculty of Pharmacy, University Paris Sud XI, 5 rue J B Clement, 92290 Chatenay-Malabry, France. iuliana.popa@u-psud.fr
Telephone: +33-01-46835750
Received: May 28, 2014
Peer-review started: May 28, 2014
First decision: July 30, 2014
Revised: October 10, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: February 2, 2015
Processing time: 120 Days and 14 Hours
Peer-review started: May 28, 2014
First decision: July 30, 2014
Revised: October 10, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: February 2, 2015
Processing time: 120 Days and 14 Hours
Core Tip
Core tip: The review concerns the literature on modifi-cations of sphingolipids in the stratum corneum (SC) of atopic dogs. We gave for the first time a detailed biochemical analysis of dog lipids in the successive layers of the SC take by tape stripping, and discussed their specificity by comparison to humans. We showed also the specific composition in protein-bound ceramides and the importance of CerOS in dog skin for barrier integrity. The lipid composition of involved and non-involved skin areas in atopic dogs was described and we showed how a topical or oral treatment can restore the lipid composition of SC and reconstruct the barrier integrity.