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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
Looking within the lesion: Large scale transcriptional profiling of psoriatic plaques
Claudia Mimoso, Miroslav Blumenberg, RO Perelman Department of Dermatology, Department of Biochemistry and Molecular Pharmacology, NYU Cancer Institute, NYU Langone Medical Center, New York, NY 10016, United States
Author contributions: Mimoso C, Blumenberg M contributed to the manuscript.
Correspondence to: Miroslav Blumenberg, PhD, RO Perelman Department of Dermatology, Department of Biochemistry and Molecular Pharmacology, NYU Cancer Institute, NYU Langone Medical Center, 455 First Avenue, New York, NY 10016, United States. miroslav.blumenberg@nyumc.org
Telephone: +1-212-2635924 Fax: +1-212-2638752
Received: November 22, 2013
Revised: January 23, 2014
Accepted: March 13, 2014
Published online: May 2, 2014
Processing time: 179 Days and 9.4 Hours
Revised: January 23, 2014
Accepted: March 13, 2014
Published online: May 2, 2014
Processing time: 179 Days and 9.4 Hours
Core Tip
Core tip: Dermatology was among the first medical specialties to adopt bioinformatics methodology, and Psoriasis, with its high prevalence, among the first diseases. Genome-wide association studies identified close to 50 genetic predisposition loci, to date. Recently, large-scale transcriptome analysis using DNA microarrays identified the important signaling pathways and regulators of gene expression in psoriasis. These efforts, and the fundamental knowledge they provide will lead to personalized medicine, i.e., to specific, individualized treatments of psoriatic patients in the near future.