Dalamaga M, Papadavid E. Metabolic co-morbidities and psoriasis: The chicken or the egg? World J Dermatol 2013; 2(4): 32-35 [DOI: 10.5314/wjd.v2.i4.32]
Corresponding Author of This Article
Maria Dalamaga, MD, PhD, MS, MPH, Assistant Professor, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, 1 Rimini street, Karyotaki 29, 12462 Athens, Greece. madalamaga@med.uoa.gr
Research Domain of This Article
Dermatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Dermatol. Nov 2, 2013; 2(4): 32-35 Published online Nov 2, 2013. doi: 10.5314/wjd.v2.i4.32
Metabolic co-morbidities and psoriasis: The chicken or the egg?
Maria Dalamaga, Evangelia Papadavid
Maria Dalamaga, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, 12462 Athens, Greece
Evangelia Papadavid, Department of Dermatology, Medical School, University of Athens, “Attikon” General University Hospital, 12462 Athens, Greece
Author contributions: Dalamaga M designed the editorial and wrote the manuscript; Papadavid E reviewed the manuscript.
Correspondence to: Maria Dalamaga, MD, PhD, MS, MPH, Assistant Professor, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, 1 Rimini street, Karyotaki 29, 12462 Athens, Greece. madalamaga@med.uoa.gr
Telephone: +30-210-5831915 Fax: +30-210-6082467
Received: June 15, 2013 Revised: September 25, 2013 Accepted: October 17, 2013 Published online: November 2, 2013 Processing time: 138 Days and 14.9 Hours
Core Tip
Core tip: Psoriasis is associated with an increased risk of obesity, metabolic syndrome (Mets) and diabetes mellitus type 2, following a “dose-response” relationship from mild to severe psoriasis. Conversely, recent evidence from large prospective studies suggests that obesity constitutes a risk factor for psoriasis and psoriatic arthritis. Both obesity, Mets and psoriasis, characterized as chronic inflammatory states, stem from a shared underlying pathophysiology exhibiting common genetic predisposition and risk factors such as high caloric intake, physical inactivity and psychological stress. Larger population-based prospective cohort and longitudinal studies are needed to unravel the association between psoriasis and metabolic co-morbidities.
