Dalamaga M, Papadavid E. Adipocytokines and psoriasis: Insights into mechanisms linking obesity and inflammation to psoriasis. World J Dermatol 2013; 2(4): 27-31 [DOI: 10.5314/wjd.v2.i4.27]
Corresponding Author of This Article
Maria Dalamaga, MD, PhD, MS, MPH, Assistant Professor, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, Karyotaki 29, 15344 Athens, Greece. madalamaga@med.uoa.gr
Research Domain of This Article
Dermatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Dermatol. Nov 2, 2013; 2(4): 27-31 Published online Nov 2, 2013. doi: 10.5314/wjd.v2.i4.27
Adipocytokines and psoriasis: Insights into mechanisms linking obesity and inflammation to psoriasis
Maria Dalamaga, Evangelia Papadavid
Maria Dalamaga, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, Chaidari, 12462 Athens, Greece
Evangelia Papadavid, Department of Dermatology, Medical School, University of Athens, “Attikon” General University Hospital, Chaidari, 12462 Athens, Greece
Author contributions: Dalamaga M designed the editorial and wrote the manuscript; Papadavid E reviewed the manuscript.
Correspondence to: Maria Dalamaga, MD, PhD, MS, MPH, Assistant Professor, Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, Karyotaki 29, 15344 Athens, Greece. madalamaga@med.uoa.gr
Telephone: +30-210-5831915 Fax: +30-210-6082467
Received: June 1, 2013 Revised: June 26, 2013 Accepted: July 4, 2013 Published online: November 2, 2013 Processing time: 54 Days and 8.2 Hours
Core Tip
Core tip: Adipocytokines could serve as a missing link in the association between psoriasis, obesity and metabolic co-morbidities. In chronic inflammatory disease states such as psoriasis, adipocytokines may be implicated in psoriasis onset, progression, severity as well as in the pathogenesis of co-morbidities. Measuring serum adipocytokine levels in the future may be useful in predicting psoriasis severity, progression, treatment outcome and risk of any co-morbidities. Interventions to decrease pro-inflammatory adipocytokine levels could offer preventive and therapeutic options for improving psoriasis severity and protecting against its co-morbidities. Candidate strategic interventions may incorporate increased physical activity, weight control and pharmacologic approaches such as metformin.
