Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Platelet-rich plasma application in diabetic ulcers: A review
Victoria Pereira Simão, Carolina Souza Cury, Gabriel Mota Zamariolli Tavares, Gabriel Calixto Ortega, Arthur Cichetto Ribeiro, Medical School, Centro Universitário Lusíada, Santos 11045-101, São Paulo, Brazil
Gabriel Silva Santos, Biomedical Science, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, São Paulo, Brazil
José Fábio Santos Duarte Lana, Department ofOrthopedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, São Paulo, Brazil
Author contributions: Simão VP wrote the manuscript; Santos GS proposed the research subtopics; Cury CS and Tavares GMZ were responsible for navigating the literature and sharing the relevant studies that were included in this review; Lana JFSD shared significant knowledge regarding the use of PRP in regenerative medicine; Ortega GC formatted the citations and compiled the references; Ribeiro AC revised and formatted the body of the manuscript, verifying spelling, punctuation and grammatical errors.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gabriel Silva Santos, BSc, Academic Research, Instructor, Research Scientist, Technician, Biomedical Science, Brazilian Institute of Regenerative Medicine, 1386 Presidente Kennedy Avenue, Indaiatuba 13334-170, São Paulo, Brazil.
Received: December 15, 2021
Peer-review started: December 15, 2021
First decision: March 16, 2022
Revised: March 29, 2022
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: June 2, 2022
Processing time: 166 Days and 13.9 Hours
Peer-review started: December 15, 2021
First decision: March 16, 2022
Revised: March 29, 2022
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: June 2, 2022
Processing time: 166 Days and 13.9 Hours
Core Tip
Core Tip: Platelet-rich plasma (PRP) can be produced by the centrifugation of a patient's peripheral blood, separating the mixture into distinct layers containing plasma, platelets, leukocytes and erythrocytes. An elevated concentration of platelets above the basal value enables accelerated growth of bone and soft tissues with minimal side effects. Autologous PRP administration is a relatively new biotechnology undergoing expansion which continues to reveal optimistic results in the stimulation and enhanced healing of various sorts of tissue injuries.