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World J Dermatol. May 2, 2015; 4(2): 108-113
Published online May 2, 2015. doi: 10.5314/wjd.v4.i2.108
New innovation of moisturizers containing non-steroidal anti-inflammatory agents for atopic dermatitis
Montree Udompataikul
Montree Udompataikul, Skin Center, Srinakharinwirot University, Bangkok 10110, Thailand
Author contributions: Udompataikul M contributed to this work.
Conflict-of-interest: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Montree Udompataikul, MD, Associate Prefessor, Skin Center, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand. umontree@yahoo.com
Telephone: +66-225-94260
Received: September 15, 2014
Peer-review started: September 16, 2014
First decision: October 14, 2014
Revised: November 27, 2014
Accepted: January 15, 2015
Article in press: January 19, 2015
Published online: May 2, 2015
Processing time: 224 Days and 21.8 Hours
Abstract

Atopic dermatitis is a chronic, relapsing and extremely pruritic eczematous disease which commonly affects children. The standard management consists of a combination of anti-inflammatory drugs in adjunctive with skin care management particular moisturizer application. A concern for the side effects associated with long term use of corticosteroids has also been considered. There has been an emerging interest in moisturizer containing non-steroidal anti-inflammatory agents such as herbal extracts, vitamins, mineral and lipids. The in vitro and the in vivo studies of each agent were reviewed. The clinical study on the efficacy of moisturizers containing these agents were also demonstrated including the author’s studies and clinical experience. These moisturizers might be considered as an alternative treatment in acute flare of mild to moderate atopic dermatitis.

Keywords: Non-steroidal anti-inflammatory agents; Moisturizer; Atopic dermatitis

Core tip: The skin care management particular moisturizers play an important role in atopic dermatitis. The side effects of corticosteroids are limited in their use in this disease. Take together, a new moisturizer containing various anti-inflammatory substances have been developed to be used as an alternative treatment to avoid the side effects of corticosteroids. These agents are divided into herbal extracts, vitamins, minerals and lipids. The clinical trials on the effectiveness of these moisturizers were reviewed. The author’s clinical experience also discussed.