Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Oct 18, 2017; 8(10): 754-760
Published online Oct 18, 2017. doi: 10.5312/wjo.v8.i10.754
Bone regeneration with osteogenic matrix cell sheet and tricalcium phosphate: An experimental study in sheep
Tsutomu Kira, Manabu Akahane, Shohei Omokawa, Takamasa Shimizu, Kenji Kawate, Tadanobu Onishi, Yasuhito Tanaka
Tsutomu Kira, Takamasa Shimizu, Tadanobu Onishi, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Nara 634-8522, Japan
Manabu Akahane, Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine, Nara 634-8522, Japan
Shohei Omokawa, Department of Hand Surgery, Nara Medical University, Nara 634-8522, Japan
Kenji Kawate, Department of Artificial Joint and Regenerative Medicine for Bone and Cartilage, Nara Medical University, Nara 634-8522, Japan
Author contributions: Kira T designed the study and conducted the animal experiments; Akahane M and Shimizu T conducted biological analysis; Omokawa S designed the study and interpreted the results; Kawate K and Onishi T conducted the data analysis; Tanaka Y interpreted the results.
Supported by Grant-in-Aid for scientific research from the Ministry of Health, Labour and Welfare, Japan.
Institutional animal care and use committee statement: All experimental protocols using animals were approved by the institutional animal care and use committee of Nara Medical University before experiments commenced.
Conflict-of-interest statement: There is no conflict of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tsutomu Kira, MD, PhD, Department of Orthopedic Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. gs212005@naramed-u.ac.jp
Telephone: +81-744-223051 Fax: +81-744-256449
Received: February 12, 2017
Peer-review started: February 15, 2017
First decision: March 27, 2017
Revised: June 13, 2017
Accepted: July 7, 2017
Article in press: July 10, 2017
Published online: October 18, 2017
Core Tip

Core tip: An osteogenic matrix cell sheet derived from sheep bone marrow enhances osteogenic differentiation. We found that the osteogenic matrix cell sheets on tricalcium phosphate discs efficiently promotes bone formation.