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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Bone and high-density lipoprotein: The beginning of a beautiful friendship
Dionysios J Papachristou, Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, University of Patras, School of Medicine, 26504 Rion-Patras, Greece
Dionysios J Papachristou, Harry C Blair, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, United States
Harry C Blair, Pittsburgh VA Medical Center, Pittsburgh, PA 15261, United States
Author contributions: Papachristou DJ conceived the general idea of the paper; Papachristou DJ and Blair HC wrote the paper.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dionysios J Papachristou, MD, PhD, Consultant Histopathologist, Associate Professor, Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, University of Patras, School of Medicine, University Campus, Building of Preclinical Studies, 2nd Floor, Room B48, 26504 Rion-Patras, Greece. papachristoudj@med.upatras.gr
Telephone: +30-2610-969188 Fax: +30-2610-969178
Received: July 5, 2015
Peer-review started: July 13, 2015
First decision: September 22, 2015
Revised: November 7, 2015
Accepted: December 1, 2015
Article in press: December 2, 2015
Published online: February 18, 2016
Peer-review started: July 13, 2015
First decision: September 22, 2015
Revised: November 7, 2015
Accepted: December 1, 2015
Article in press: December 2, 2015
Published online: February 18, 2016
Core Tip
Core tip: Recent evidence suggests that high-density lipoprotein (HDL) metabolic pathways are closely related to bone and cartilage homeostasis. In this editorial the authors briefly present the current knowledge concerning the mechanisms that link HDL and cartilage and bone metabolism and discuss the role of HDL result in the development of the most common bone pathological conditions, osteoarthritis and osteoporosis. These data add to the appreciation of bone and lipid connection and pave the way towards the development of novel HDL-related strategies for the treatment of these diseases.