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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Cytokines as biochemical markers for knee osteoarthritis
Thomas Mabey, Sittisak Honsawek, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
Author contributions: Mabey T and Honsawek S solely contributed to this paper.
Supported by Ratchadapiseksompotch Fund (RA55/22), Faculty of Medicine, Chulalongkorn University and Office of the Higher Education Commission (CU-NRU, Aging Society Cluster).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sittisak Honsawek, MD, PhD, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Pathumwan, Bangkok 10330, Thailand. sittisak.h@chula.ac.th
Telephone: +662-256-4482 Fax: +662-256-4482
Received: December 5, 2013
Peer-review started: December 8, 2013
First decision: March 12, 2014
Revised: March 24, 2014
Accepted: July 17, 2014
Article in press: July 17, 2014
Published online: January 18, 2015
Processing time: 410 Days and 11.6 Hours
Peer-review started: December 8, 2013
First decision: March 12, 2014
Revised: March 24, 2014
Accepted: July 17, 2014
Article in press: July 17, 2014
Published online: January 18, 2015
Processing time: 410 Days and 11.6 Hours
Core Tip
Core tip: This review discusses the role and significance of cytokines implicated in the pathophysiology and development of knee osteoarthritis. We aim to describe and summarize the current knowledge and advancement of the use of cytokines as biochemical markers in diagnosis and management of knee osteoarthritis (OA). Cytokines play an important role in the pathogenesis of OA. A better understanding of the biological mechanisms involved in this process may result in better treatment for OA patients. Biomarker investigation for OA diagnosis is still in the forefront of the research repertoire in OA. This review highlights some biomarker studies published in the PubMed database.