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World J Orthop. Apr 18, 2014; 5(2): 151-157
Published online Apr 18, 2014. doi: 10.5312/wjo.v5.i2.151
Published online Apr 18, 2014. doi: 10.5312/wjo.v5.i2.151
Clinical results of linezolid in arthroplasty and trauma MRSA related infections
James Joel, Adam Peckham-Cooper, Academic Orthopaedic and Trauma Unit, Leeds Teaching Hospitals, Leeds School of Medicine, Leeds LS1 3EX, United Kingdom
Simon Matthew Graham, Royal Liverpool University Hospital, Liverpool L7 8XP, United Kingdom
Nectarios Korres, Helen Tsouchnica, Eleftherios Tsiridis, Academic Orthopaedics and Trauma Unit, Division of Surgery, Aristotle University Medical School, University Campus, 54 124 Thessaloniki, Greece
Author contributions: Joel J, Graham SM and Peckham-Cooper A contributed equally to this work in designing, writing and editing the paper; Korres N and Tsouchnica H assisted with the data collection; Tsiridis E designed the study and oversaw all areas of data collection and writing up of the paper.
Correspondence to: Eleftherios Tsiridis, MD, MSc, DMed, PhD, FRCS, Associate Professor of Orthopaedics and Trauma, Academic Orthopaedic and Trauma Unit, Division of Surgery, Aristotle University Medical School, University Campus, Kiriakidi 1, 54 124 Thessaloniki, Greece. etsiridis@doctors.org.uk
Telephone: +30-210-3620666 Fax: +30-210-3620666
Received: October 17, 2013
Revised: February 10, 2014
Accepted: March 3, 2014
Published online: April 18, 2014
Processing time: 214 Days and 11.2 Hours
Revised: February 10, 2014
Accepted: March 3, 2014
Published online: April 18, 2014
Processing time: 214 Days and 11.2 Hours
Core Tip
Core tip: Our study demonstrates that linezolid delivers excellent oral bioavailability, with good penetration into bone, joints and soft tissue. It exhibits action against gram-positive organisms, including methicillin resistant Staphylococcus aureus and vancomycin resistant enterococci, and it is ideally suited for the variety of infections encountered in orthopaedic practice. Used in conjunction with surgical management, excellent results can be achieved in resolving infection.