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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Orthop. Oct 18, 2013; 4(4): 327-332
Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.327
Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.327
Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia
Haris S Vasiliadis, Christina Arnaoutoglou, Sotiris Plakoutsis, Theodoros A Xenakis, Department of Orthopaedics, University Hospital of Ioannina, 45500 Ioannina, Greece
Michalis Doukas, Anna Batistatou, Department of Pathology, University Hospital of Ioannina, 45500 Ioannina, Greece
Author contributions: Vasiliadis HS, Doukas M, Batistatou A and Xenakis TA designed research; Vasiliadis HS, Plakoutsis S and Doukas M performed research; Plakoutsis S, Doukas M and Batistatou A contributed new reagents or analytic tools; Vasiliadis HS, Arnaoutoglou C, Doukas M, Batistatou A and Xenakis TA analyzed data; Vasiliadis HS, Arnaoutoglou C and Plakoutsis S wrote the paper; Vasiliadis HS, Arnaoutoglou C and Xenakis TA performed surgical operation; Doukas M and Batistatou A performed histological evaluation.
Correspondence to: Haris S Vasiliadis MD, PhD, Department of Orthopaedics, University Hospital of Ioannina, Panepistimiou 4, 45500 Ioannina, Greece. vasiliadismd@gmail.com
Telephone: +30-26-51099682 Fax: +30-26-51093245
Received: February 20, 2013
Revised: June 7, 2013
Accepted: June 19, 2013
Published online: October 18, 2013
Processing time: 249 Days and 19.7 Hours
Revised: June 7, 2013
Accepted: June 19, 2013
Published online: October 18, 2013
Processing time: 249 Days and 19.7 Hours
Core Tip
Core tip: We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. Although open biopsy suggested fibrous dysplasia, clinical and radiological evaluation indicated malignancy. Histological examination of the excised specimen revealed central low-grade osteosarcoma. Central low-grade osteosarcoma is a rare, well-differentiated, sub-type of osteosarcoma, with clinical, imaging, and histological features in keeping with benign tumours. Thus, initial misdiagnosis is common, typically being mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery in isolation, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision.