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World J Orthop. Oct 18, 2013; 4(4): 229-240
Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.229
Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.229
Healing of subcutaneous tendons: Influence of the mechanical environment at the suture line on the healing process
Elsayed Ibraheem Elsayed Massoud, Orthopaedic Department, Sohag Teaching Hospital, General Organization for Teaching Hospitals and Institutes, 82521 Tahta, Sohag, Egypt
Author contributions: Massoud EIE solely contributed to this paper.
Correspondence to: Elsayed Ibraheem Elsayed Massoud, MD, Orthopaedic Department, Sohag Teaching Hospital, General Organization for Teaching Hospitals and Institutes, Nile St., 82521 Tahta, Sohag, Egypt. elsayedmassoud@hotmail.com
Telephone: +20-93-4771639 Fax: +20-93-4783639
Received: June 26, 2013
Revised: August 5, 2013
Accepted: August 28, 2013
Published online: October 18, 2013
Processing time: 124 Days and 7.3 Hours
Revised: August 5, 2013
Accepted: August 28, 2013
Published online: October 18, 2013
Processing time: 124 Days and 7.3 Hours
Core Tip
Core tip: Ruptured tendons heal poorly compared to skin, muscles and bones. Immobilization during repair has been shown to be detrimental for the healing process. Mechanical loading of the tendon callus gives rise to intracellular signaling, increases gene expression and protein synthesis. However, early loading reported clinical complications. A surgical technique based on control of the mechanical environment at the suture line provided satisfactory results. Therefore, understanding the interplay between loading and the healing process seems necessary. This review focuses on the biological processes that regulate tendon repair and timing of mechanical loading during the healing process. How do tendon cells sense mechanical forces?