Karmakar A, Jaiswal A, Mandal S, Khan AA, Mitra M. Therapeutic efficacy of thiocolchicoside-nonsteroidal anti-inflammatory drug combination in pain management: A systematic review and cross-sectional real-world study. World J Orthop 2025; 16(8): 106769 [DOI: 10.5312/wjo.v16.i8.106769]
Corresponding Author of This Article
Monjori Mitra, Professor, Visiting Professor, Department of Pediatrics, Institute of Child Health, 11 Biresh Guha Street, Kolkata 700017, West Bengal, India. monjorimr@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Aug 18, 2025; 16(8): 106769 Published online Aug 18, 2025. doi: 10.5312/wjo.v16.i8.106769
Therapeutic efficacy of thiocolchicoside-nonsteroidal anti-inflammatory drug combination in pain management: A systematic review and cross-sectional real-world study
Arnab Karmakar, Akash Jaiswal, Soham Mandal, Afroz Ahmed Khan, Monjori Mitra
Arnab Karmakar, Department of Orthopedics, Institute of Post Graduate Medical Education and Research, Kolkata 700020, West Bengal, India
Akash Jaiswal, Department of Orthopedics, Apollo Hospital, Secunderabad 500025, Telangana, India
Soham Mandal, Department of Orthopedics, Manipal Hospital, Kolkata 700106, West Bengal, India
Afroz Ahmed Khan, Department of Orthopedics, Era's Lucknow Medical College and Hospital, Lucknow 226003, Uttar Pradesh, India
Monjori Mitra, Department of Pediatrics, Institute of Child Health, Kolkata 700017, West Bengal, India
Author contributions: Mitra M provided the resources; Karmakar A, Jaiswal A, Mandal S, Khan AA, and Mitra M conceived the study, designed the methodology, performed the formal analyses, validated the data, participated in project administration, wrote, reviewed, and edited the manuscript; All authors have reviewed the manuscript and agreed to its publication.
Supported by CORONA Remedies Limited.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Monjori Mitra, Professor, Visiting Professor, Department of Pediatrics, Institute of Child Health, 11 Biresh Guha Street, Kolkata 700017, West Bengal, India. monjorimr@gmail.com
Received: March 6, 2025 Revised: June 6, 2025 Accepted: July 7, 2025 Published online: August 18, 2025 Processing time: 155 Days and 0.6 Hours
Core Tip
Core Tip: This systematic review demonstrates the enhanced therapeutic efficacy of combining thiocolchicoside (TCC) with nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management, supported by real-world data from 156713 patients. Our analysis revealed that combination therapy provided superior pain relief, improved functional outcomes, and increased patient satisfaction compared to NSAID monotherapy, without a significant rise in adverse events. Notably, patients receiving the combination were significantly more likely to achieve clinically meaningful pain reduction. These findings support the combined use of TCC and NSAIDs in clinical practice, particularly for musculoskeletal and postoperative pain, to optimize patient outcomes and recovery.
