Shastov AL, Kolchin SN, Malkova TA. Effectiveness of the induced membrane technique in aseptic and infected long-bone defect management: Are there any differences? World J Orthop 2025; 16(7): 107337 [DOI: 10.5312/wjo.v16.i7.107337]
Corresponding Author of This Article
Tatiana A Malkova, Department of Medical Information and Analysis, Ilizarov National Medical Research Center for Traumatology and Orthopaedics, 6, M. Ulianova street, Kurgan 640014, Russia. tmalkova@mail.ru
Research Domain of This Article
Orthopedics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Jul 18, 2025; 16(7): 107337 Published online Jul 18, 2025. doi: 10.5312/wjo.v16.i7.107337
Effectiveness of the induced membrane technique in aseptic and infected long-bone defect management: Are there any differences?
Alexander L Shastov, Sergey N Kolchin, Tatiana A Malkova
Alexander L Shastov, Bone Infection Clinic, Ilizarov National Medical Research Center for Traumatology and Orthopaedics, Kurgan 640014, Kurganskaya Oblast’, Russia
Sergey N Kolchin, Orthopaedic Department 4, Ilizarov National Medical Research Center for Traumatology and Orthopaedics, Kurgan 640014, Kurganskaya Oblast’, Russia
Tatiana A Malkova, Department of Medical Information and Analysis, Ilizarov National Medical Research Center for Traumatology and Orthopaedics, Kurgan 640014, Kurganskaya Oblast’, Russia
Author contributions: Shastov AL was responsible for selection of literature on infected nonunion and defects treated with induced membrane technique, manuscript text writing and revising; Kolchin SN was responsible for selection of literature on aseptic nonunion and defects treated with induced membrane technique, manuscript text writing and revising; Malkova TA was responsible for selection of literature on induced membrane technique for bone nonunion and defects, manuscript text writing, editing and revising.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tatiana A Malkova, Department of Medical Information and Analysis, Ilizarov National Medical Research Center for Traumatology and Orthopaedics, 6, M. Ulianova street, Kurgan 640014, Russia. tmalkova@mail.ru
Received: March 28, 2025 Revised: April 27, 2025 Accepted: June 7, 2025 Published online: July 18, 2025 Processing time: 112 Days and 3.7 Hours
Core Tip
Core Tip: The induced membrane (IM) technique (IMT) has been mostly used for severe long bone defects due to open fractures and infected nonunion. The clinical studies available show its performance and outcomes on relatively small samples of patients and they are mostly infected cases. The surgeon should adequately resect non-vital tissues to prevent bone auto- or allograft lysis due to possible reinfection. The IMT gives a chance for the infection to heal after thorough debridement within the waiting period during stage 1. Its implementation frequently needs soft-tissue procedures and several grafting materials to add into the IM in critical size defects. Internal fixation is a preferred method of bone fixation to avoid the risks of external fixation complications. The interval between the stages and duration of antibiotics administration are longer in infected cases.
