Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Apr 18, 2025; 16(4): 104452
Published online Apr 18, 2025. doi: 10.5312/wjo.v16.i4.104452
Effectiveness of oral vs intravenous acetaminophen on pain management following total joint arthroplasty: A systematic review and meta-analysis
Bin Lu, Ai-Xian Tian, Zheng-Rui Fan, Xing-Wen Zhao, Hong-Zhen Jin, Jian-Xiong Ma, Xin-Long Ma
Bin Lu, Ai-Xian Tian, Zheng-Rui Fan, Xing-Wen Zhao, Hong-Zhen Jin, Jian-Xiong Ma, Xin-Long Ma, Biomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Tianjin University, Tianjin 300050, China
Author contributions: All authors certified that they have participated in the conceptual design of this work, the analysis of the data, and the writing of the manuscript to take public responsibility for it; Lu B and Tian AX drafted the protocol and wrote the final paper; Ma JX and Ma XL contributed to the research design and made critical revisions; Fan ZR, Zhao XW and Jin HZ participated in data collection; Lu B and Tian AX participated in the data analysis; all authors reviewed the final version of the manuscript and approve it for publication.
Supported by National Natural Science Foundation of China, No. 11772226 and No. 81572154.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Long Ma, Biomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Tianjin University, No. 155 Munan Road Heping District, Tianjin 300050, China. maxinlong8686@sina.com
Received: December 24, 2024
Revised: March 5, 2025
Accepted: April 1, 2025
Published online: April 18, 2025
Processing time: 117 Days and 23.2 Hours
Core Tip

Core Tip: Oral acetaminophen shows similar pain management after total joint arthroplasty (TJA) which compared with intravenous acetaminophen. Intravenous acetaminophen was not found to be superior to oral acetaminophen in patients undergoing TJA in terms of visual analogue scale score at 24, 48 h, total morphine consumption. However, it can significantly reduce the length of hospital stay. Higher-quality randomized controlled trials are required for further research in the future.