Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Feb 18, 2025; 16(2): 102101
Published online Feb 18, 2025. doi: 10.5312/wjo.v16.i2.102101
Novel association between chronic obstructive pulmonary disease and osteoporosis: A prospective cross-sectional study
Rong Gao, Jian-Kang Zeng, Kai Yang, Ping Wang, Sheng Zhou
Rong Gao, Jian-Kang Zeng, Kai Yang, Ping Wang, Sheng Zhou, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Rong Gao, Kai Yang, Ping Wang, Sheng Zhou, Department of Diagnostic Radiology, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China
Co-first authors: Rong Gao and Jian-Kang Zeng.
Author contributions: Gao R and Yang K contributed to writing and reviewing the manuscript; Gao R and Wang P contributed to designing the survey and executing the study; Gao R, Zhou S, and Wang P contributed to the statistics and reviewing the manuscript; All authors have reviewed and approved the final manuscript. Gao R and Zeng JK contributed equally to the conception and design of the study and are co-first authors.
Supported by National Natural Science Foundation of China (NSFC) of China, No. 82360358; Internal Medicine Research Project of Gansu Provincial People's Hospital, No. 22GSSYD-77; and Natural Science Foundation of Gansu Province, No. 22JR5RA659.
Institutional review board statement: Ethical approval for this study was obtained from Gansu Provincial People's Hospital, No. 2023-304.
Informed consent statement: Participants were informed about the study’s purpose, methods, and voluntary nature, with the option to withdraw at any time. By voluntarily participating, informed consent was implied. No identifiers were collected, and the anonymity and confidentiality of participants were strictly maintained.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement-a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: Raw data and materials are available upon reasonable request to the Corresponding Author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng Zhou, MD, Professor, Department of Diagnostic Radiology, Gansu Provincial Hospital, No. 204 Donggang West Road, Lanzhou 730000, Gansu Province, China. lzzs@sina.com
Received: October 8, 2024
Revised: December 18, 2024
Accepted: January 11, 2025
Published online: February 18, 2025
Processing time: 126 Days and 12.2 Hours
Core Tip

Core Tip: This study investigated the relationship between bone mineral density (BMD) and lung function, mainly the forced expiratory volume in 1 second (FEV1)/forced vital capacity percentage (FVC%), in patients with chronic obstructive pulmonary disease (COPD). A significant non-linear association was observed, and BMD ≤ 128.08 mg/cm³ was considered a critical threshold for lung function assessment. Higher BMD values correlated positively with higher FEV1/FVC%, suggesting that BMD may be a valuable biomarker for evaluating lung function changes in this population. These findings provide new insights into the interplay between bone health and respiratory function in patients with COPD.