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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Jan 18, 2025; 16(1): 99690
Published online Jan 18, 2025. doi: 10.5312/wjo.v16.i1.99690
Published online Jan 18, 2025. doi: 10.5312/wjo.v16.i1.99690
Current status of nanofat in the management of knee osteoarthritis: A systematic review
Naveen Jeyaraman, Sandeep Shrivastava, Arulkumar Nallakumarasamy, Department of Orthopaedics, Datta Meghe Institute of Higher Education and Research, Wardha 442004, Maharashtra, India
Naveen Jeyaraman, VR Ravi, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Department of Regenerative Medicine, Mother Cell Regenerative Centre, Tiruchirappalli 620017, Tamil Nadu, India
Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India
Author contributions: Jeyaraman N designed the research; Jeyaraman N and Nallakumarasamy A performed the literature review and wrote the manuscript; Shrivastava S, Ravi VR, and Jeyaraman M finalized the manuscript; Jeyaraman M made the figures; All authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Madhan Jeyaraman, MS, PhD, Assistant Professor, Research Associate, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India.
Received: July 28, 2024
Revised: December 7, 2024
Accepted: December 25, 2024
Published online: January 18, 2025
Processing time: 169 Days and 1.5 Hours
Revised: December 7, 2024
Accepted: December 25, 2024
Published online: January 18, 2025
Processing time: 169 Days and 1.5 Hours
Core Tip
Core Tip: The systematic review establishes that nanofat therapy is a promising intervention for osteoarthritis (OA), offering both pain relief and functional improvement, while also maintaining a favorable safety profile. The therapy's underlying mechanisms include the enhancement of chondrocyte proliferation, reduction of inflammation, and promotion of angiogenesis. Despite these promising findings, the study underscores the need for additional research, particularly in the form of large-scale randomized controlled trials, to validate the long-term efficacy and safety of nanofat therapy in the management of OA.