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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Jan 18, 2025; 16(1): 97848
Published online Jan 18, 2025. doi: 10.5312/wjo.v16.i1.97848
Published online Jan 18, 2025. doi: 10.5312/wjo.v16.i1.97848
Limited evidence to support demineralized bone matrix in foot and ankle surgical procedures: A systematic review
Hayden Hartman, Department of Medicine, Lincoln Memorial University, Knoxville, TN 37752, United States
James J Butler, Charles C Lin, Samantha Rettig, Jared C Tishelman, Sebastian Krebsbach, Grace W Randall, John G Kennedy, Department of Orthopedic Surgery, NYU Langone Health, New York, NY 10002, United States
Megan Calton, Department of Medicine, Royal College of Surgeons in Ireland, Dublin D02 YN77, Leinster, Ireland
Author contributions: Hartman H was involved in data analysis, concept creation, and writing of the first draft of the manuscript, and editing of the first draft of the manuscript; Butler JJ was involved in search term generation, data analysis, writing of the first draft of the manuscript, and table creation; Lin CC was involved in data extraction, data analysis, editing of the first draft of the manuscript, and figure creation; Rettig S was involved in data analysis, figure creation, and writing of the first draft of the manuscript; Tishelman JC was involved in data extraction, table creation, and editing of the first and second draft of the manuscript; Krebsbach S was involved in data extraction, table creation, and editing of the second draft of the manuscript; Randall GW was involved in data extraction and figure/table creation; Kennedy JG was involved in concept creation, data analysis, writing of the first draft of the manuscript, and editing of the first and second draft of the manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: John G Kennedy, FRCS, MCh, MD, MSc, Chief, Professor, Department of Orthopedic Surgery, NYU Langone Health, 171 Delancey Street, New York, NY 10002, United States. john.kennedy@nyulangone.org
Received: June 10, 2024
Revised: October 28, 2024
Accepted: December 25, 2024
Published online: January 18, 2025
Processing time: 216 Days and 9.9 Hours
Revised: October 28, 2024
Accepted: December 25, 2024
Published online: January 18, 2025
Processing time: 216 Days and 9.9 Hours
Core Tip
Core Tip: Despite the prevalent use of demineralized bone matrix in foot and ankle surgeries, this systematic review uncovers a lack of robust evidence supporting its efficacy. While it demonstrates satisfactory osseous union rates and favorable complication profiles, the insufficiency of high-quality studies and significant heterogeneity across research call for caution in its clinical application, emphasizing the need for further well-designed investigations to establish its effectiveness definitively.