Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Jan 18, 2025; 16(1): 101656
Published online Jan 18, 2025. doi: 10.5312/wjo.v16.i1.101656
Teriparatide as a non-surgical salvage therapy for prolonged humerus fracture nonunion: A case report and literature review
Shao-Han Guo, Chong Li, Yi-Jun Gao, Zhen Zhang, Ke Lu
Shao-Han Guo, Chong Li, Yi-Jun Gao, Ke Lu, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou 215300, Jiangsu Province, China
Zhen Zhang, Department of Radiology, Affiliated Kunshan Hospital of Jiangsu University, Suzhou 215300, Jiangsu Province, China
Author contributions: Guo SH drafted the manuscript; Guo SH and Zhang Z contributed to the acquisition of data; Li C and Lu K approved the final manuscript; Gao YJ and Lu K revised the manuscript; Lu K contributed to the study conception and design; Guo SH, Li C, Gao YJ, Zhang Z, Lu K were all involved in the diagnosis, management, and care of the patient; all of the authors read and approved the final version of the manuscript to be published.
Supported by National Natural Science Foundation of China, No. 82172441; Suzhou City Major Disease Multicenter Clinical Research Project, No. DZXYJ202312; Special Funding for Jiangsu Province Science and Technology Plan (Key Research and Development Program for Social Development), No. BE2023737; Gusu Health Talent Plan Scientific Research Project, No. GSWS2022109; and Postgraduate Research and Practice Innovation Program of Jiangsu Province, No. SJCX24_2446.
Informed consent statement: Informed consent was obtained from all individual patients included in the study.
Conflict-of-interest statement: All authors state they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ke Lu, MD, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, No. 566 East of Qianjin Road, Suzhou 215300, Jiangsu Province, China. sgu8434@sina.com
Received: September 22, 2024
Revised: December 12, 2024
Accepted: January 2, 2025
Published online: January 18, 2025
Processing time: 112 Days and 19.9 Hours
Core Tip

Core Tip: This case report highlights the successful use of teriparatide, a recombinant form of parathyroid hormone, in a patient with a four-year history of nonunion following a humeral fracture. This is the first documented case of teriparatide being used to treat nonunion of such prolonged duration. The report underscores the role of teriparatide in bone regeneration and repair, demonstrating its potential as a valuable non-surgical treatment option when conventional therapies have failed.