Platelet rich plasma and anterior cruciate ligament repair: A new frontier, or a short term adjunct

doi:10.5312/wjo.v16.i1.100693

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Jan 18, 2025 (publication date) through Mar 19, 2025

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Jan 18, 2025; 16(1): 100693
Published online Jan 18, 2025. doi: 10.5312/wjo.v16.i1.100693

Platelet rich plasma and anterior cruciate ligament repair: A new frontier, or a short term adjunct

Saran Singh Gill, Giulia Cenci, Susanna Falcinelli, Fabrizio Marzano, Bruno Carriero, Nicola Filippi, Valerio Pace

Saran Singh Gill, Faculty of Medicine, Imperial College London, London SW72AZ, United Kingdom

Giulia Cenci, Susanna Falcinelli, Bruno Carriero, Valerio Pace, Department of Trauma and Orthopaedics, AOSP Terni, Terni 05100, Umbria, Italy

Fabrizio Marzano, Department of Trauma and Ortopaedics, Ospedale Degli Infermi, Faenza 48018, Italy

Nicola Filippi, Orthopaedic and Traumatology Unit, Department of Knee Surgery, ASL Viterbo, Viterbo 01100, Italy

Author contributions: Pace V received the invitation; Gill SS, Cenci G, Falcinelli S, Marzano F, Carriero B, Filippi N and Pace V designed the article, performed research and literature review, analyzed data, wrote and finalized the review; all of the authors read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Valerio Pace, Department of Trauma and Orthopaedics, AOSP Terni, Via Joannuccio, Terni 05100, Umbria, Italy. valeriopace@doctors.org.uk

Received: August 23, 2024
Revised: November 21, 2024
Accepted: December 11, 2024
Published online: January 18, 2025
Processing time: 143 Days and 1.4 Hours

Core Tip

Core Tip: Platelet rich plasma (PRP) shows promise in enhancing early healing and reducing complications in anterior cruciate ligament reconstruction, though its long-term efficacy remains inconsistent. Optimizing PRP formulations and targeted research are essential to fully realize its therapeutic potential. PRP could serve as both an adjunct and non-surgical alternative in anterior cruciate ligament treatments, potentially revolutionizing patient recovery in orthopaedics and sports medicine.