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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Sep 18, 2024; 15(9): 870-881
Published online Sep 18, 2024. doi: 10.5312/wjo.v15.i9.870
Published online Sep 18, 2024. doi: 10.5312/wjo.v15.i9.870
Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature
Christian J Rajkovic, Matthew L Merckling, Alyssa W Lee, Galadu Subah, Aryan Malhotra, Zachary D Thomas, Sabrina L Zeller, John V Wainwright, Merritt D Kinon, Department of Neurosurgery, Westchester Medical Center, Valhalla, NY 10595, United States
Co-corresponding authors: Christian J Rajkovic and Merritt D Kinon.
Author contributions: Rajkovic CJ was responsible for designing the review protocol, writing the protocol and report, conducting the search, screening potentially eligible studies, extracting and analyzing data, interpreting results, writing the manuscript, updating reference lists, and creating figures and tables; Merckling ML was responsible for screening potentially eligible studies, extracting and analyzing data, interpreting results, and writing the manuscript; Lee AW was responsible for screening potentially eligible studies and creating the PRISMA figure; Malhotra A, Thomas ZD was responsible for screening potentially eligible studies; Subah G, Zeller SL, Wainwright JV and Kinon MD was responsible for designing the review protocol, screening potentially eligible studies, assessing bias in included studies, writing the manuscript, and providing feedback.
Conflict-of-interest statement: Dr. Merritt Kinon reports stock and honorarium with Globus Medical, Inc and is a consultant for Sanara MedTech. The remaining authors have no conflicts of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christian J Rajkovic, BSc, Researcher, Department of Neurosurgery, Westchester Medical Center, 40 Sunshine Cottage Road, Valhalla, NY 10595, United States.
Received: March 18, 2024
Revised: August 22, 2024
Accepted: August 28, 2024
Published online: September 18, 2024
Processing time: 178 Days and 1 Hours
Revised: August 22, 2024
Accepted: August 28, 2024
Published online: September 18, 2024
Processing time: 178 Days and 1 Hours
Core Tip
Core Tip: Injections of autologous conditioned serum (ACS) are an emerging conservative management strategy for reducing inflammation and pain in various osteoarthritic conditions. This therapy extracts and amplifies the novel anti-inflammatory molecule, interleukin-1 receptor antagonist, in a patient's serum for autologous treatment of inflammation. This study systematically reviews the literature for articles investigating the effectiveness of ACS in improving pain, disability, and quality of life in patients with spinal pathology.