Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Aug 18, 2024; 15(8): 813-819
Published online Aug 18, 2024. doi: 10.5312/wjo.v15.i8.813
Hemophagocytic lymphohistiocytosis triggered by relapsing polychondritis: A case report
Mi-Ran Han, Jeong-Hwan Hwang, Seungah Cha, So-Yeon Jeon, Kyu Yun Jang, Namsu Kim, Chang-Hoon Lee
Mi-Ran Han, Jeong-Hwan Hwang, Seungah Cha, So-Yeon Jeon, Chang-Hoon Lee, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea
Kyu Yun Jang, Department of Pathology, Jeonbuk National University Medical School, Jeonju 54907, South Korea
Namsu Kim, Department of Laboratory Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea
Author contributions: Han MR wrote the manuscript; Cha S, Jang KY, and Kim NS collected and validated the data; Hwang JH and Jeon SY revised the manuscript; Lee CH was in charge of patient treatment and designed the manuscript; All authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang-Hoon Lee, MD, PhD, Assistant Professor, Doctor, Department of Internal Medicine, Jeonbuk National University Medical School, 20 Geonji-ro, Jeonju 54907, South Korea. rednose2000@hanmail.net
Received: May 15, 2024
Revised: July 17, 2024
Accepted: July 26, 2024
Published online: August 18, 2024
Processing time: 90 Days and 6.5 Hours
Core Tip

Core Tip: Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition typically triggered in adults by conditions such as cancer, infections, and autoimmune disorders, resulting in immune system over-activation. Relapsing polychondritis (RP), an uncommon disease, is diagnosed through physical examination. In contrast to primary HLH, which necessitates stem cell transplantation is the only definitive cure, acquired HLH can be managed with therapies such as chemotherapy and immunosuppressive therapy, tailored to the underlying cause. The patient received treatment for HLH using RP therapies and was successfully cured with methylprednisolone (1 mg/kg) and azathioprine.