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World J Orthop. Aug 18, 2024; 15(8): 704-712
Published online Aug 18, 2024. doi: 10.5312/wjo.v15.i8.704
Intra-articular interventions in osteoarthritis: Navigating the landscape of hyaluronic acid, mesenchymal stem cells, and platelet-rich plasma
Somar Soufan, Joenne Al Khoury, Zahi Hamdan, Mohamad Ali Rida
Somar Soufan, Joenne Al Khoury, Zahi Hamdan, Department of Medicine, University of Balamand, Beirut 00000, Lebanon
Mohamad Ali Rida, Department of Internal Medicine, Clemenceau Medical Center, Beirut 12345, Lebanon
Author contributions: Soufan S, Hamdan Z and Al Khoury J designed and wrote the manuscript; Soufan S, Hamdan Z, Al Khoury J and Rida MA did the literature review; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mohamad Ali Rida, MD, Assistant Professor, Department of Internal Medicine, Clemenceau Medical Center, Clemenceau, Beirut 12345, Lebanon. mohamad.ali.rida@gmail.com
Received: April 25, 2024
Revised: July 13, 2024
Accepted: July 29, 2024
Published online: August 18, 2024
Processing time: 109 Days and 14.9 Hours
Core Tip

Core tip: Osteoarthritis significantly affects patients by causing pain, functional decline, and reduced quality of life. Traditional treatments mainly manage symptoms, with no disease-modifying interventions established. This review examines intra-articular treatments, including hyaluronic acid (HA), mesenchymal stem cells (MSCs), and platelet-rich plasma (PRP). HA injections show varied outcomes, requiring detailed understanding. MSCs, especially adipose-derived MSCs, demonstrate sustained benefits over 6 mo, while bone-marrow-derived MSCs are less effective. PRP is effective for long-term pain relief and quality of life improvement. Personalized, evidence-based approaches are crucial to enhance treatment efficacy and patient outcomes.