Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis
Xu-Chang Zhou, Dong-Xue Wang, Chun-Yu Zhang, Ya-Jing Yang, Ruo-Bing Zhao, Sheng-Yao Liu, Guo-Xin Ni
Xu-Chang Zhou, Dong-Xue Wang, Chun-Yu Zhang, Ruo-Bing Zhao, School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China
Ya-Jing Yang, Department of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China
Sheng-Yao Liu, Department of Spinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China
Guo-Xin Ni, Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China
Co-first authors: Xu-Chang Zhou and Dong-Xue Wang.
Author contributions: Ni GX and Zhou XC designed and coordinated the study; Wang DX and Yang YJ performed the experiments, acquired and analyzed data; Zhao RB interpreted the data; Zhou XC and Liu SY acquired the Fund; Zhou XC and Wang DX wrote the manuscript; all authors approved the final version of the article.
Supported by the Key Laboratory of Sports and Physical Health of the Ministry of Education (Beijing Sport University), the Fundamental Research Funds for the Central Universities, No. 20221021; the Guangzhou Science and Technology Plan Project, No. 202102020536; and the Plan on Enhancing Scientific Research in GMU.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Beijing Sport University (Approval Number: 2023026A).
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Guo-Xin Ni, MD, PhD, Chief Doctor, Chief Physician, Professor, Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen 361003, Fujian Province, China. nigx@xmu.edu.cn
Received: November 22, 2023
Peer-review started: November 22, 2023
First decision: January 24, 2024
Revised: February 4, 2024
Accepted: March 19, 2024
Article in press: March 19, 2024
Published online: April 18, 2024
