Adipose-derived stem cells and knee osteoarthritis: New perspectives, old concerns

doi:10.5312/wjo.v15.i11.1001

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Nov 18, 2024 (publication date) through Nov 15, 2024

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Nov 18, 2024; 15(11): 1001-1006
Published online Nov 18, 2024. doi: 10.5312/wjo.v15.i11.1001

Adipose-derived stem cells and knee osteoarthritis: New perspectives, old concerns

Eduardo B de Sousa, José Paulo A Gabbi Filho, Vinicius S Gameiro, Leandra S Baptista

Eduardo B de Sousa, Vinicius S Gameiro, Department of General and Specialized Surgery, Fluminense Federal University, Rio de Janeiro 24070-090, Brazil

José Paulo A Gabbi Filho, Department of Orthopaedics, Quinta D’Or Hospital, Rio de Janeiro 20941-150, Brazil

Leandra S Baptista, Duque de Caxias Campus Prof Geraldo Cidade, Federal University of Rio de Janeiro, Rio de Janeiro 25065-050, Brazil

Author contributions: de Sousa EB, Gabbi Filho JPA, Gameiro VS, and Baptista LS conceived and planned the activities that led to the paper, participated in the review process, and formatting of the article and approved the final version.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Eduardo B de Sousa, MD, PhD, Department of General and Specialized Surgery, Fluminense Federal University, Rua Ataíde Parreiras 100, Rio de Janeiro 24070-090, Brazil. eduardobranco.joelho@gmail.com

Received: May 29, 2024
Revised: October 16, 2024
Accepted: November 5, 2024
Published online: November 18, 2024
Processing time: 170 Days and 2.8 Hours

Core Tip

Core Tip: Adipose tissue has been described being superior to bone marrow as a source mesenchymal stem cell due to its lower invasiveness and higher cell content. Hence, products derived from the adipose tissue for the treatment of knee osteoarthritis represent a potential perspective of treatment. However, although most papers describe their potential use, papers present heterogenous protocols heterogeneity in for harvesting and delivery represent a concern.