Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Jul 18, 2023; 14(7): 547-553
Published online Jul 18, 2023. doi: 10.5312/wjo.v14.i7.547
Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty: A prospective observational study
Davide Bizzoca, Andrea Piazzolla, Lorenzo Moretti, Giovanni Vicenti, Biagio Moretti, Giuseppe Solarino
Davide Bizzoca, Andrea Piazzolla, Lorenzo Moretti, DAI Neuroscienze, Organi di Senso e Apparato Locomotore, AOU Consorziale Policlinico di Bari, Bari 70124, Italy
Giovanni Vicenti, Biagio Moretti, Giuseppe Solarino, Di BraiN, University of Bari "Aldo Moro", Bari 70124, Italy
Author contributions: Bizzoca D, Moretti B and Solarino G designed the research study; Bizzoca D and Vicenti G performed the research; Bizzoca D wrote the manuscript; Moretti L and Piazzolla A revised the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study was approved by the local Ethics Committee of AOU Policlinico di Bari (No. 6919).
Informed consent statement: Written informed consent was obtained from the patients.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at giuseppe.solarino@uniba.it.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—a checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed following the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Giuseppe Solarino, MD, PhD, Associate Professor, Di BraiN, University of Bari "Aldo Moro", Piazza Giulio Cesare, 11, Bari 70124, Italy. giuseppe.solarino@uniba.it
Received: December 23, 2022
First decision: March 1, 2023
Revised: March 9, 2023
Accepted: June 12, 2023
Article in press: June 12, 2023
Published online: July 18, 2023
Processing time: 206 Days and 14.4 Hours
Core Tip

Core Tip: The dosage of plasmatic presepsin (PS) concentration is highly recommended in patients undergoing total hip arthroplasty before surgery to exclude the presence of an unknown infection. The PS plasmatic concentration should be also assessed at 72 h post-operatively, to evaluate the maximum postoperative PS value, and at 96 h post-operatively when a decrease of presepsin should be found. The lack of a presepsin decrease at 96 h post-operatively should be a predictive factor of infection.