Case Control Study
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World J Orthop. Sep 18, 2022; 13(9): 791-801
Published online Sep 18, 2022. doi: 10.5312/wjo.v13.i9.791
Histological difference in ligament flavum between degenerative lumbar canal stenosis and non-stenotic group: A prospective, comparative study
Mantu Jain, Mukund Sable, Amit Purushottam Tirpude, Rabi Narayan Sahu, Sudeep Kumar Samanta, Gurudip Das
Mantu Jain, Sudeep Kumar Samanta, Gurudip Das, Department of Orthopaedics, All India Institute of Medical Sciences Bhubaneswar, Bhuabneswar 751019, Odisha, India
Mukund Sable, Department of Pathology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India
Amit Purushottam Tirpude, Department of Anatomy, All India Institute of Medical Sciences Raipur, Raipur 492009, Chattisgarh, India
Rabi Narayan Sahu, Department of Neurosurgery, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India
Author contributions: Jain M, Sable B, Tirpude AP, and Sahu RN conceived the idea; Jain M got the ethical clearance and grant for the study; Jain M, Sahu RN, and Das G collected the sample; Sable M and Tirpude AP performed the histological analysis; The data were compiled by Jain M and Samanta SK; Sable M and Jain M performed the statistical analysis; Jain M, Samanta SK, and Das G wrote the manuscript, whereas the other authors provided critical inputs; All authors have read and agree to the content of the manuscript.
Supported by Institutional research grant (AIIMS Bhubaneswar).
Institutional review board statement: The study was reviewed and approved by the Institutional ethics committee of AIIMS Bhubaneswar (T/IM/18-19/43 dated 04/01/2019).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mantu Jain, MD, Doctor, Surgeon, Department of Orthopaedics, All India Institute of Medical Sciences Bhubaneswar, Bhuabneswar 751019, Odisha, India. montu_jn@yahoo.com
Received: January 17, 2022
Peer-review started: January 17, 2022
First decision: February 21, 2022
Revised: March 2, 2022
Accepted: August 24, 2022
Article in press: August 24, 2022
Published online: September 18, 2022
Processing time: 241 Days and 17.8 Hours
Core Tip

Core Tip: The ligament flavum (LF) is vital in the pathogenesis of lumbar canal stenosis (LCS). The purely elastic LF undergoes a morphological adaptation that includes a reduction in the elastic fibers with a consequent increase in the collagen content, fibrosis, cicatrization, and calcification. The present study provides a detailed morphometric analysis to semiquantitatively delineate the LF changes in patients with LCS from those in patients without LCS.