Sankova MV, Nikolenko VN, Oganesyan MV, Vovkogon AD, Gadzhiakhmedova AN, Zharikova TS, Zharikov YO. Identifying sex-specific injury predictors as a key factor in maintaining optimal physical activity levels. World J Orthop 2023; 14(3): 146-154 [PMID: 36998385 DOI: 10.5312/wjo.v14.i3.146]
Corresponding Author of This Article
Yury O Zharikov, MD, PhD, Associate Professor, Surgeon, Department of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Mokhovaya Street, 11s10, Moscow 125009, Russia. dr_zharikov@mail.ru
Research Domain of This Article
Orthopedics
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Mar 18, 2023; 14(3): 146-154 Published online Mar 18, 2023. doi: 10.5312/wjo.v14.i3.146
Identifying sex-specific injury predictors as a key factor in maintaining optimal physical activity levels
Maria V Sankova, Vladimir N Nikolenko, Marine V Oganesyan, Andjela D Vovkogon, Aida N Gadzhiakhmedova, Tatyana S Zharikova, Yury O Zharikov
Maria V Sankova, Vladimir N Nikolenko, Marine V Oganesyan, Andjela D Vovkogon, Tatyana S Zharikova, Yury O Zharikov, Department of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 125009, Russia
Vladimir N Nikolenko, Marine V Oganesyan, Tatyana S Zharikova, Department of Normal and Topographic Anatomy, Lomonosov Moscow State University, Moscow 119991, Russia
Andjela D Vovkogon, European Osteopathic Clinical Center of the Moscow Branch of the “Medical Academy of Osteopathic Education”, Saint Petersburg 199106, Russia
Aida N Gadzhiakhmedova, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
Author contributions: Sankova MV, Oganesyan MV, and Vovkogon AD involved in the conceptualization of the manuscript; Sankova MV, Nikolenko VN, Oganesyan MV, Vovkogon AD, and Zharikov YO contributed to the methodology of this article; Sankova MV, Oganesyan MV, Vovkogon AD, and Gadzhiakhmedova AN participated to the resources; Sankova MV analysed data; Sankova MV and Oganesyan MV wrote the original draft preparation; Sankova MV, Oganesyan MV, Zharikova TS and Zharikov YO wrote the review and editing; Nikolenko VN, Oganesyan MV, Vovkogon AD and Zharikov YO involved in the project administration; and all authors have read and agreed to the published manuscript version.
Institutional review board statement: The current research study was approved by the Ethics Committee of I.M. Sechenov First Moscow State Medical University (Sechenov University) under protocol No. 08-19 on 05.06.2019.
Informed consent statement: Informed consent was obtained from the participants included in this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yury O Zharikov, MD, PhD, Associate Professor, Surgeon, Department of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Mokhovaya Street, 11s10, Moscow 125009, Russia. dr_zharikov@mail.ru
Received: October 17, 2022 Peer-review started: October 17, 2022 First decision: January 3, 2023 Revised: January 11, 2023 Accepted: February 27, 2023 Article in press: February 27, 2023 Published online: March 18, 2023 Processing time: 150 Days and 17.1 Hours
ARTICLE HIGHLIGHTS
Research background
At present, sports medicine is of particular importance in the regular medical-biological support of people engaged in physical exercise and sports. Of particular importance is the detection of connective tissue pathology, which determines the increased sensitivity to mechanical stress, creates injury predisposition and impairs connective tissue recovery in the posttraumatic period, causing further injury recurrence.
Research motivation
This study was created because existing methods often do not take into account differentiated approaches to dysplasia sign assessment and connective tissue pathology diagnosis in men and women and is therefore aimed at filling this gap and creating approaches that complement existing ones.
Research objectives
The purpose of this work was to establish pathognomonic sex-specific injury phenotypes for consideration when designing exercise programs that support optimal physical activity in men and women. The results of the study were conceived as an addition to the existing methods of assessing the risk of further injury recurrence.
Research methods
In our study, we measured 117 participants with recurrent musculoskeletal injuries that occurred during normal physical activity in the absence of a pronounced traumatic factor. Musculoskeletal injuries of varying severity included sprains and ruptures of the joint ligament apparatus, dislocations and tendon tears. Anthropometric parameters and indices indicating the presence of signs of connective tissue dysplasia were studied. An analysis was also performed to identify differences in the presence of signs between sexes. A validated questionnaire was used to screen the connective tissue state.
Research results
In our research, we studied the ranking of the most commonly revealed dysplasia signs depending on their clinical significance, making it possible to establish pathognomonic sex-specific phenotypes that indicate a particular susceptibility to injuries.
Research conclusions
The study results are of particular importance in the context of physical culture and sport safety and emphasize the importance of a differentiated approach of medico- biological support of sports activities in men and women.
Research perspectives
To further develop these findings, it is possible to conduct a larger-scale study with a larger number of participants. Further refinement of the sex-specific dysplasia phenotypes is needed for clarification and, possibly, expansion of these findings. With satisfactorily refined results, it is possible to introduce the proposed methodology into practice for a clinical trial.
