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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Safety and outcomes of hip and knee replacement surgery in liver transplant recipients
Mohamed Ahmed, Abdelrhman Abumoawad, Fouad Jaber, Hebatullah Elsafy, Saqr Alsakarneh, Laith Al Momani, Alisa Likhitsup, John H Helzberg
Mohamed Ahmed, Fouad Jaber, Saqr Alsakarneh, Department of Internal Medicine, University of Missouri Kansas City, Kansas City, MO 64108, United States
Abdelrhman Abumoawad, Department of Vascular Medicine, Boston University, Boston, MA 02215, United States
Hebatullah Elsafy, Department of Pathology, Kansas University, Kansas City, MO 66160, United States
Laith Al Momani, John H Helzberg, Department of Gastroenterology, University of Missouri Kansas City, Kansas City, MO 64110, United States
Alisa Likhitsup, Department of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, United States
Author contributions: Ahmed M contributed to the conception and literature review of the manuscript; Ahmed M, Abumoawad A, and Elsafy H designed this study; Ahmed M and Jaber F drafted the manuscript; Abumoawad A collected the data; Jaber F, Al Momani L, Likhitsup A, and Helzberg JH involved in the critical reviewing of the manuscript; Elsafy H contributed to the analytic plan; Helzberg JH supervised and edited the manuscript.
Institutional review board statement: This study is performed based on the Healthcare Cost and Utilization Project databases. The HIPAA Privacy Rule sets national standards for patient rights with respect to health information. This rule protects individually identifiable health information by establishing conditions for its use and disclosure by covered entities.
Informed consent statement: This study is performed based on the Healthcare Cost and Utilization Project databases. The HIPAA Privacy Rule sets national standards for patient rights with respect to health information. This rule protects individually identifiable health information by establishing conditions for its use and disclosure by covered entities.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: This study is performed based on the Healthcare Cost and Utilization Project databases.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Mohamed Ahmed, MD, MSc, Doctor, Department of Internal Medicine, University of Missouri Kansas City, 2301 Holmes Street, Kansas City, MO 64108, United States. mohamedfayez1991@gmail.com
Received: July 15, 2023
Peer-review started: July 15, 2023
First decision: August 14, 2023
Revised: September 13, 2023
Accepted: October 23, 2023
Article in press: October 23, 2023
Published online: November 18, 2023
ARTICLE HIGHLIGHTS
Research background
Solid organ transplants are rising with recipients having longer life span. This puts them at risk of needing joint replacement surgery during their life time. The outcomes of these surgeries are understudied which raises the need for studies to evaluate benefits and risks in this cohort.
Research motivation
The question is whether patients with liver transplant (LT) are at increased risk of developing complication or have a higher mortality when needing hip or knee replacement surgery.
Research objectives
The main objective is to prove the LT patients are not at increased risk of complications when needing hip or knee replacement surgery which will allow these patients to get this surgery when needed. Also, this study aims to identify factors associated with increased morbidity which can help modify these factors.
Research methods
Patients were selected from the Healthcare Cost and Utilization Project databases (HCUP). The HCUP databases are sponsored by the Agency for Healthcare Research and Quality. The International Classification of Diseases Code, 10th Revision Clinical Modification was used to identify the patients.
Research results
Patients with a history of LT undergoing knee or hip replacement have longer hospital stay, increase morbidity but no increase mortality as compared to patient with no history of LT.
Research conclusions
The results show that hip and knee replacement are safe procedures in patients with LT.
Research perspectives
More research is needed in identifying risk scores to stratify LT patients as either high or low risk for joint replacement surgery.
