Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Apr 18, 2021; 12(4): 214-222
Published online Apr 18, 2021. doi: 10.5312/wjo.v12.i4.214
Osseointegration of porous titanium and tantalum implants in ovariectomized rabbits: A biomechanical study
Stanislav Bondarenko, Volodymyr Filipenko, Michael Karpinsky, Olena Karpinska, Gennadiy Ivanov, Valentyna Maltseva, Ahmed Amine Badnaoui, Ran Schwarzkopf
Stanislav Bondarenko, Volodymyr Filipenko, Ahmed Amine Badnaoui, Department of Joint Pathology, Sytenko Institute of Spine and Joint Pathology, Kharkiv 61124, Ukraine
Michael Karpinsky, Olena Karpinska, Department of Biomechanics, Sytenko Institute of Spine and Joint Pathology, Kharkiv 61124, Ukraine
Gennadiy Ivanov, Department of Experimental Pathology, Sytenko Institute of Spine and Joint Pathology, Kharkiv 61124, Ukraine
Valentyna Maltseva, Morphology of Connective Tissue Department, Sytenko Institute of Spine and Joint Pathology, Kharkiv 61124, Ukraine
Ran Schwarzkopf, Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, Hospital for Joint Diseases, New York, NY 10003, United States
Author contributions: All authors contributed to the study conception and design; Bondarenko S, Maltseva V, and Badnaoui AA wrote the first draft of the manuscript; Filipenko V supervised the study and performed critical revisions of the article; Karpinsky M and Karpinska O analyzed the data; Ivanov G performed experimental surgery, collected, and interpreted data; Schwarzkopf R performed critical revisions of the article; All authors revised and approved the final version of the manuscript.
Institutional review board statement: Sytenko Institute of Spine and Joint Pathology Review board.
Institutional animal care and use committee statement: All applicable national guidelines for the care and use of animals were followed. The in vivo study was approved by the Ethical Clearance Bioethics Committee State Institution “Sytenko Institute of Spine and Joint Pathology NAMS of Ukraine”, Kharkiv, Ukraine (Protocol No. 175 of 26 Feb 2018).
Conflict-of-interest statement: Bondarenko S, Filipenko V, Karpinsky M, Karpinska O, Ivanov G, Maltseva V, and Badnaoui AA declare that they have no conflict of interest. Schwarzkopf R has potential competing interests; he is a paid consultant of Smith & Nephew, Memphis, TN, United States.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stanislav Bondarenko, DSc, MD, PhD, Associate Professor, Department of Joint Pathology, Sytenko Institute of Spine and Joint Pathology, Pushkinska St. 80, Kharkiv 61124. Ukraine. bondarenke@gmail.com
Received: September 10, 2020
Peer-review started: September 10, 2020
First decision: January 27, 2021
Revised: February 1, 2021
Accepted: March 11, 2021
Article in press: March 11, 2021
Published online: April 18, 2021
Processing time: 213 Days and 20.8 Hours
ARTICLE HIGHLIGHTS
Research background

Highly porous metal acetabular components are widely used in patients with low bone mass, but the strength of osseointegration may differ.

Research motivation

There is a need to perform studies to compare the strength of osseintegration of new porous metal biomaterials used in total hip arthroplasty of patients with low bone mass.

Research objectives

The objective of this study was to compare the strength of the formed bonе-metal osseointegration among four types of porous metal biomaterials in an in vivo animal model with both normal bone and after simulation of osteoporosis

Research methods

The experimental study was performed in a rabbit model of postmenopausal osteoporosis. Biomechanical evaluation of the femur was carried out by testing the implant breakout force 8 wk after implantation of four types of biomaterials: TTM, CONCELOC, Zimmer Biomet's Trabecular Metal (TANTALUM), and ATLANT. The force was gradually increased until complete detachment of the implant from the bone.

Research results

The breakout force needed for implant detachment was significantly higher in healthy controls, compared with the ovariectomized group for all implants. The breakout force for ATLANT in the ovariectomized group was lower than that observed with TANTALUM, CONCELOC’ and TTM.

Research conclusions

TANTALUM, TTM and CONCELOC had equal bone-implant osseointegration in healthy and osteoporotic bones. ATLANT showed a significant decrease in osseointegration in healthy and osteoporotic bone.

Research perspectives

Further studies on the use of other biomechanical methods will expand the knowledge of the strength of osseointegration of modern porous materials, which will help in choosing optimal materials for acetabular implants when performing total hip arthroplasty in patients with osteoporosis.