Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Mar 18, 2020; 11(3): 184-196
Published online Mar 18, 2020. doi: 10.5312/wjo.v11.i3.184
Systematic review of the etiology behind patellar clunk syndrome
Sean Bertram Sequeira, James Scott, Wendy Novicoff, Quanjun Cui
Sean Bertram Sequeira, James Scott, Wendy Novicoff, Quanjun Cui, Department of Orthopedic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, United States
Author contributions: Cui Q conceived the study idea and designed the research with Scott J; Sequeira SB wrote the manuscript and analyzed the data; Sequeira SB collected the data; Sequeira SB, Cui Q, Novicoff W, and Scott J edited and revised the manuscript.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Quanjun Cui, MD, G.J. Wang Professor of Orthopedic Surgery, Vice Chair for Research, Department of Orthopedic Surgery, University of Virginia School of Medicine, 400 Ray C Hunt Dr, Charlottesville, VA 22908, United States. qc4q@hscmail.mcc.virginia.edu
Received: September 28, 2019
Peer-review started: September 28, 2019
First decision: December 24, 2019
Revised: December 24, 2019
Accepted: January 19, 2020
Article in press: January 19, 2020
Published online: March 18, 2020
ARTICLE HIGHLIGHTS
Research background

Patellar clunk syndrome (PCS) is a postoperative complication following total knee arthroplasty that clinically presents as anterior knee pain that is particularly painful when going from full flexion to extension. The pathoanatomy of PCS involves the accumulation of scar tissue along the undersurface of the quadriceps tendon, proximal to the superior pole of the patella. The diagnosis of PCS can often be made clinically, but radiographic adjuncts such as ultrasound and magnetic resonance imaging have been used with success. Unfortunately, there is no current literature that evaluates multiple metrics of the native knee and prosthesis to determine what metric is most responsible for the development of PCS.

Research motivation

The main topics of the current study are (1) characterizing and analyzing metrics implicated in the pathogenesis of PCS; and (2) defining contemporary management, treatment, and preventative algorithms for PCS. The current study aims to elucidate how various prosthesis and geometries of native knee can cause PCS or prevent it from occurring, which are poorly summarized and defined in the literature currently.

Research objectives

The main objective of the current study is to evaluate current evidence and characterize a reasonable etiology for the development of PCS. A secondary objective of the current study is to better understand the various treatment and preventative heuristics implemented to manage PCS.

Research methods

A systematic review of clinical research studies from PubMed, Google Scholar, and Cochrane was conducted, as these databases were felt to be representative of peer-reviewed scholarly work and well encompassed literature surrounding PCS. Each study was analyzed and results were compiled in designated tables with a predetermined list of metrics and its corresponding incidence of PCS. Details regarding prevention, treatment, and management were also extracted at this time.

Research results

A total of 30 articles were identified through the primary search, with an additional 3 included from reference lists of the primary search. Results indicate that prosthesis design was the most frequently cited metric as contributory towards PCS. The prosthesis design is often a combination of multiple metrics and, therefore, we conclude that the etiology of PCS is multifactorial. A reduced intercondylar box ratio and box width has been consistently shown to reduce PCS.

Research conclusions

Prosthesis design is the main metric associated with the etiology of PCS, though because the prosthesis design incorporates several other metrics included in our analysis, the etiology of PCS is multifactorial. Later prosthesis designs that incorporate a reduced intercondylar box ratio and box width can reduce development of PCS. Preventative strategies involve using later generations of prosthesis especially those that incorporate a reduced intercondylar box ratio.

Research perspectives

Overall, this study was able to confirm the etiology of PCS as well as provide insight into treatment methods to prevent this postoperative complication. Nevertheless, future studies should aim to isolate individual metrics of prosthesis design to more specifically determine which metric is most responsible for the development of PCS. Higher level randomized control trials should also be conducted to generate additional evidence to improve knee maneuverability and function post-total knee arthroplasty.