Retrospective Cohort Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Oct 18, 2019; 10(10): 348-355
Published online Oct 18, 2019. doi: 10.5312/wjo.v10.i10.348
Two-stage revision arthroplasty for coagulase-negative staphylococcal periprosthetic joint infection of the hip and knee
Ewout S Veltman, Dirk Jan F Moojen, Marc L van Ogtrop, Rudolf W Poolman
Ewout S Veltman, Dirk Jan F Moojen, Rudolf W Poolman, Department of Orthopaedic and Trauma Surgery, OLVG, Joint Research OLVG, Amsterdam 1091AC, Netherlands
Ewout S Veltman, Department of Orthopaedic Surgery, Leiden University Medical Centre, Leiden 2333ZA, Netherlands
Marc L van Ogtrop, Department of Medical Microbiology, OLVG, Amsterdam 1091AC, Netherlands
Author contributions: Veltman ES, Moojen DJF, van Ogtrop ML, and Poolman RW designed the study; Veltman ES performed extraction, synthesis, and interpretation of data; Veltman ES, Moojen DJF, van Ogtrop ML, and Poolman RW drafted and/or revised the manuscript.
Informed consent statement: This study was exempt from acquiring written informed consent by the OLVG medical ethics committee, with study number 15.080.
Conflict-of-interest statement: All authors have no conflicts of interest related to the manuscript.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised accordingly.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ewout S Veltman, MD, Doctor, Department of Orthopaedic and Trauma Surgery, OLVG, Joint Research OLVG, Oosterpark 9, Amsterdam 1091AC, Netherlands. E.s.veltman@olvg.nl
Telephone: +31-20-5108884
Received: May 20, 2019
Peer-review started: May 20, 2019
First decision: July 31, 2019
Revised: August 14, 2019
Accepted: September 4, 2019
Article in press: September 4, 2019
Published online: October 18, 2019
Processing time: 158 Days and 0.6 Hours
ARTICLE HIGHLIGHTS
Research background

Coagulase-negative Staphylococci (CoNS) are difficult-to-treat microorganisms in periprosthetic joint infections (PJIs) of the hip and knee. The resistance of these bacteria to antibiotics is increasing.

Research motivation

To date, no infection eradication rates of treatment for this type of specific infection have been reported.

Research objectives

To evaluate the infection eradication rate of two-stage revision arthroplasty for CoNS PJI of the hip and knee.

Research methods

Retrospective cohort study of all patients treated with two-stage revision for CoNS PJI of a hip or knee prosthesis.

Research results

In 33 of 44 patients, the infections were eradicated at a mean of 37 mo after two-stage revision surgery of the hip and knee.

Research conclusions

Two-stage revision surgery of the hip and knee for PJI infections with CoNS leads to infection eradication rate comparable to other causative pathogens.

Research perspectives

Two-stage revision yields an acceptable infection eradication rate for treatment of CoNS infection of the hip and knee. Future studies should consider combining cohorts of patients from multiple centres to achieve larger cohorts of patients.