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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Relationship between biological factors and catastrophizing and clinical outcomes for female patients with knee osteoarthritis
Tatsunori Ikemoto, Hirofumi Miyagawa, Yukiko Shiro, Young-Chang Park Arai, Machiko Akao, Kenta Murotani, Takahiro Ushida, Masataka Deie
Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan
Yukiko Shiro, Department of Physical Therapy, Faculty of Rehabilitation Sciences, Nagoya Gakuin University, Seto, Aichi 480-1298, Japan
Machiko Akao, Masataka Deie, Department of Orthopedic Surgery, Aichi Medical University, Nagakute, Aichi 480-1195, Japan
Kenta Murotani, Division of Biostatistics, Clinical Research Center Aichi Medical University, Nagakute 480-1195, Japan
Author contributions: Ikemoto T had conceived this research; Ikemoto T and Miyagawa H contributed equally to this work; Ikemoto T, Ushida T and Deie M did the research design; Ikemoto T, Miyagawa H and Akao M participated in the collection of the data; Ikemoto T, Shiro Y, Murotani K and Arai YCP contributed to the analysis and interpretation of the data; Ikemoto T, Shiro Y and Arai YCP prepared a first manuscript and a revised manuscript.
Institutional review board statement: The study received ethical approval from the Research Ethics Committee of Aichi Medical University, Japan (No. 12-101).
Informed consent statement: Prior to study enrollment, each subject was fully informed by the investigator 1: that content of this study and 2: that the personal information of the subject would be kept confidential.
Conflict-of-interest statement: The authors declare that there is no conflict of interest regarding the publication of this paper.
Data sharing statement: There are no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tatsunori Ikemoto, MD, PhD, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, 1-1 yazako karimata, Nagakute, Aichi 480-1195, Japan.
tatsunon31-ik@umin.ac.jp
Telephone: +81-561-611809 Fax: +81-561-625004
Received: October 13, 2016
Peer-review started: October 19, 2016
First decision: November 14, 2016
Revised: November 27, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: March 18, 2017
Processing time: 154 Days and 20.8 Hours
AIM
To investigate the correlations between clinical outcomes and biopsychological variables in female patients with knee osteoarthritis (OA).
METHODS
Seventy-seven patients with symptomatic knee OA were enrolled in this study. We investigated the age, body mass index (BMI), pain catastrophizing scale (PCS) and radiographic severity of bilateral knees using a Kellgren-Lawrence (K-L) grading system of the subjects. Subsequently, a multiple linear regression was conducted to determine which variables best correlated with main outcomes of knee OA, which were pain severity, moving capacity by measuring timed-up-and-go test and Japanese Knee Osteoarthritis Measure (JKOM).
RESULTS
We found that the significant contributor to pain severity was PCS (β = 0.555) and BMI (β = 0.239), to moving capacity was K-L grade (β = 0.520) and to PCS (β = 0.313), and to a JKOM score was PCS (β = 0.485) and K-L grade (β = 0.421), respectively.
CONCLUSION
The results suggest that pain catastrophizing as well as biological factors were associated with clinical outcomes in female patients with knee OA, irrespective of radiographic severity.
Core tip: Plenty of previous studies have focused on biological factors such as aging, gender, body mass index, ethnicity and history of knee injury for knee pain in cases where there was a discordant relationship between radiographic severity and symptoms in knee osteoarthritis (OA). However, in the present study, we found that pain catastrophizing thought was highly associated with knee-related clinical outcomes, irrespective of radiographic severity, for female patients with knee OA, especially pain severity and quality of life.
