Systematic Reviews
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Mar 18, 2015; 6(2): 311-315
Published online Mar 18, 2015. doi: 10.5312/wjo.v6.i2.311
Impact of osteoporosis in dental implants: A systematic review
Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli
Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil
Author contributions: Giro G and Chambrone L contributed equally to this work; Giro G, Chambrone L and Shibli JA designed the review; Zenóbio E, Feres M and Shibli JA analyzed the data; Giro G, Chambrone L, Cassoni A, Goldstein A, Rodrigues JA and Figueiredo LC participated of the data collection and the elaboration of the manuscript.
Supported by Sao Paulo Research Foundation, FAPESP, No. 2008/06972-6; The National Council for Scientific and Technological Development, CNPq Nos. 579157/2008-3, 302768/2009-2 and 473282/2007-0; Pesq-Doc scholarship to Dr. Shibli from University of Guaruhos and Scholarship to Dr. Giro from University of Guarulhos.
Conflict-of-interest: The authors declare that there are no conflicts of interest related to this study.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jamil Awad Shibli, Professor, DDS, PhD, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Praça Tereza Cristina 01, Guarulhos SP 07023-040, Brazil. jashibli@yahoo.com
Telephone: +55-11-24413670 Fax: +55-11-24641758
Received: May 29, 2014
Peer-review started: May 29, 2014
First decision: July 18, 2014
Revised: December 3, 2014
Accepted: January 9, 2015
Article in press: Janurary 12, 2015
Published online: March 18, 2015
Processing time: 294 Days and 8.4 Hours
Abstract

AIM: To assess the failure and bone-to-implant contact rate of dental implants placed on osteoporotic subjects.

METHODS: Extensive examination strategies were created to classify studies for this systematic review. MEDLINE (via PubMed) and EMBASE database were examined for studies in English up to and including May 2014. The examination presented a combination of the MeSH words described as follow: “osteoporosis” or “osteopenia” or “estrogen deficiency” AND “implant” or “dental implant” or “osseointegration”. Assessment of clinical and/or histological peri-implant conditions in osteoporosis subjects treated with titanium dental implants. The examination included a combination of the MeSH terms described as follow: “osteoporosis” or “osteopenia” or “estrogen deficiency” AND “implant” or “dental implant” or “osseointegration”.

RESULTS: Of 943 potentially eligible articles, 12 were included in the study. A total of 133 subjects with osteoporosis, 73 subjects diagnosed with osteopenia and 708 healthy subjects were assessed in this systematic review. In these subjects were installed 367, 205, 2981 dental implants in osteoporotic, osteopenic and healthy subjects, respectively. The failure rate of dental implant was 10.9% in osteoporotic subjects, 8.29% in osteopenic and 11.43% in healthy ones. Bone-to-implant contact obtained from retrieved implants ranged between 49.96% to 47.84%, for osteoporosis and non-osteoporotic subjects.

CONCLUSION: Osteoporotic subjects presented higher rates of implant loss, however, there is a lower evidence to strengthen or refute the hypothesis that osteoporosis may have detrimental effects on bone healing. Consequently, final conclusions regarding the effect of osteoporosis in dental implant therapy cannot be made at this time. There are no randomized clinical trial accessible for evaluation and the retrospective nature of the evaluated studies shall be taken in account when interpreting this study.

Keywords: Dental implants; Osteoporosis; Failures; Osteopenia; Osseointegration

Core tip: This systematic review focused on failure rates and percentage of osseointegration of dental implants in healthy and osteoporotic subjects. Definitive conclusions regarding the impact of osteoporosis on dental implant therapy cannot be made at this time. Clinically, it could be suggested that osteoporotic subjects can receive dental implant therapy.