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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review
Bruna Trazzi Pagani, Marcelie Priscila de Oliveira Rosso, Matheus Bento Medeiros Moscatel, Beatriz Flavia de Moraes Trazzi, Marcelo Rodrigues da Cunha, João Paulo Mardegan Issa, Daniela Vieira Buchaim, Rogério Leone Buchaim
Bruna Trazzi Pagani, Matheus Bento Medeiros Moscatel, Beatriz Flavia de Moraes Trazzi, Dentistry School, University of Marilia, Marilia 17525-902, Brazil
Marcelie Priscila de Oliveira Rosso, Department of Physiotherapy, Physical Education and Biomedicine, Estácio de Sá School of Ourinhos, Ourinhos 19907-510, Brazil
Marcelo Rodrigues da Cunha, Interunit Graduate Program in Bioengineering, University of Sao Paulo, Sao Carlos 13566-970, Brazil
Marcelo Rodrigues da Cunha, Postgraduate Program in Health Sciences, Faculty of Medicine of Jundiaí, Jundiai 13202-550, Brazil
João Paulo Mardegan Issa, Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirao Preto 14040-904, Brazil
Daniela Vieira Buchaim, Medical School, University Center of Adamantina, Adamantina 17800-000, Brazil
Daniela Vieira Buchaim, Rogério Leone Buchaim, Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, Brazil
Rogério Leone Buchaim, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil
Author contributions: Pagani BT, Rosso MPO, and Buchaim RL contributed to conceptualization, original draft preparation, writing, review, editing, and visualization of the study; Pagani BT, Trazzi BFM, and Cunha MR contributed to conceptualization; Rosso MPO contributed to validation, research, and data curation; Rosso MPO and Buchaim RL contributed to the methodology and formal analysis; Moscatel MBM, Trazzi BFM, Cunha MR, Issa JPM and Buchaim DV contributed to the methodology, validation, and formal analysis; Moscatel MBM, Trazzi BFM, and Buchaim DV contributed to data curation and visualization; Cunha MR and Issa JPM contributed to validation and formal analysis; Rosso MPO participated in formal analysis, investigation, data curation, original draft preparation, writing, review, editing, and visualization; Buchaim RL contributed to writing, review, editing, and supervision.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Rogério Leone Buchaim, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla 9-75, Bauru 17012-901, Brazil.
rogerio@fob.usp.br
Received: February 18, 2025
Revised: April 1, 2025
Accepted: April 21, 2025
Published online: May 18, 2025
Processing time: 87 Days and 10.1 Hours
BACKGROUND
Bone regeneration is a central focus of regenerative medicine, with applications in orthopedics and dentistry, particularly for treating bone defects caused by trauma, infection, or congenital anomalies. Synthetic biomaterials, often combined with fibrin derivatives, offer promising solutions for bone healing and restoration.
AIM
To Explore the increasingly important role of the association of synthetic biomaterials with fibrin in bone regeneration.
METHODS
Search terms included: “synthetic biomaterials AND fibrin sealant”, “hydroxyapatite AND fibrin sealant”, “tricalcium phosphate AND fibrin sealant”, and “synthetic biomaterials AND platelet-rich fibrin (PRF)”, resulting in 67 articles. After rigorous screening, 21 articles met the inclusion criteria.
RESULTS
The reviewed studies assessed biomaterials like hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and fibrin-based products. Key findings highlighted the enhanced osteoconductivity and biocompatibility of HA and β-TCP, especially when combined with fibrin sealants. These composites show significant potential for improving cellular adhesion, promoting osteogenic differentiation, and accelerating bone regeneration. The antimicrobial properties and structural support for cell growth of certain biomaterials indicate a promising potential for clinical applications.
CONCLUSION
This systematic review emphasizes the growing role of fibrin-based biomaterials in bone regeneration and urges continued research to improve their clinical use for complex bone defects.
Core Tip: The integration of synthetic biomaterials and fibrin composites is a promising strategy in regenerative medicine, demonstrating high biocompatibility and effectiveness in bone formation. It also represents progress in the pursuit of more accessible and clinically applicable solutions for bone reconstruction.
