Hidajat NN, Magetsari RMSN, Steven G, Budiman J, Prasetiyo GT. Platelet-rich plasma for de Quervain’s tenosynovitis: A systematic review and meta-analysis. World J Orthop 2024; 15(9): 858-869 [DOI: 10.5312/wjo.v15.i9.858]
Corresponding Author of This Article
Nucki Nursjamsi Hidajat, FICS, MD, Doctor, Surgeon, Department of Orthopaedics and Traumatology, Padjadjaran University, Jalan Pasteur No. 38, Bandung 45363, Jawa Barat, Indonesia. nucki@unpad.ac.id
Research Domain of This Article
Orthopedics
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Sep 18, 2024; 15(9): 858-869 Published online Sep 18, 2024. doi: 10.5312/wjo.v15.i9.858
Platelet-rich plasma for de Quervain’s tenosynovitis: A systematic review and meta-analysis
Nucki Nursjamsi Hidajat, Raden Moechammad Satrio Nugroho Magetsari, Gregorius Steven, Jethro Budiman, Gregorius Thomas Prasetiyo
Nucki Nursjamsi Hidajat, Raden Moechammad Satrio Nugroho Magetsari, Gregorius Thomas Prasetiyo, Department of Orthopaedics and Traumatology, Padjadjaran University, Bandung 45363, Jawa Barat, Indonesia
Gregorius Steven, Jethro Budiman, General Practitioner, Panti Wilasa Citarum Hospital, Semarang 50121, Indonesia
Author contributions: Hidajat NN and Magetsari RMSN A contributed to the design and implementation of the study and the writing of the manuscript; Steven G and Budiman J contributed to the statistical analyses and the writing of the manuscript; Prasetiyo GT contributed to the design of the study and the revision of the manuscript; Steven G and Budiman J contributed to the performance of the research; Magetsari RMSN and Prasetiyo GT contributed to the quality and professional revision; Hidajat NN contributed to the quality and professional revision and the writing of the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nucki Nursjamsi Hidajat, FICS, MD, Doctor, Surgeon, Department of Orthopaedics and Traumatology, Padjadjaran University, Jalan Pasteur No. 38, Bandung 45363, Jawa Barat, Indonesia. nucki@unpad.ac.id
Received: March 18, 2024 Revised: August 1, 2024 Accepted: August 28, 2024 Published online: September 18, 2024 Processing time: 177 Days and 19.6 Hours
Abstract
BACKGROUND
Platelet-rich plasma (PRP) injection is used as an alternative non-operative management for de Quervain’s tenosynovitis (DQT) to regenerate tendon healing.
AIM
To assess and conclude the research-based study systematically to analyse the efficacy of PRP on DQT.
METHODS
This systematic review used the Cochrane Handbook for Systematic Reviews and the guideline of preferred reporting items for systematic review and meta-analysis. A systematic literature search was applied to 11 databases. The authors assessed the study quality and risk of bias of each included study. Results of the meta-analysis were presented using mean difference (MD)/standardized mean difference (SMD) and 95% confidence interval (CI).
RESULTS
The authors evaluated 275 studies found in the literature search; 12 studies met the criteria for this review, and then the study quality and risk of bias were assessed. Pooled analysis of data from two studies involving 194 subjects with DQT showed that, compared with conservative treatment, PRP injection was associated with a greater reduction in visual analog scale pain in one month and six months after treatment (MD: -0.67, P value < 0.00001; MD: -1.16, P value < 0.00001) and the increase of Mayo’s wrist score in one month and six months after treatment (SMD: 3.72, P value < 0.00001; SMD: 4.44, P value < 0.00001).
CONCLUSION
PRP can be used as an alternative non-operative treatment for DQT due to the tissue regenerative effect of PRP.
Core Tip: De Quervain’s tenosynovitis (DQT) is a common tendon disorder characterized by wrist pain and tenderness at the first dorsal compartment of the wrist. Platelet-rich plasma (PRP) injection is currently used as an alternative non-operative management for DQT to regenerate tendon healing due to its tissue regenerative effect, which provides better pain management and stable improvement in functional outcomes in the long term. Ultrasonography-guided PRP with percutaneous needle tenotomy gives a better outcome. There are minimal side effects associated with PPR injection.
