Hoveidaei A, Karimi M, Khalafi V, Fazeli P, Hoveidaei AH. Impacts of radiation therapy on quality of life and pain relief in patients with bone metastases. World J Orthop 2024; 15(9): 841-849 [PMID: 39318492 DOI: 10.5312/wjo.v15.i9.841]
Corresponding Author of This Article
Amir Human Hoveidaei, MD, Research Fellow, International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, United States. hoveidaei.a.h@gmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Sep 18, 2024; 15(9): 841-849 Published online Sep 18, 2024. doi: 10.5312/wjo.v15.i9.841
Impacts of radiation therapy on quality of life and pain relief in patients with bone metastases
Armin Hoveidaei, Mehdi Karimi, Vida Khalafi, Patrick Fazeli, Amir Human Hoveidaei
Armin Hoveidaei, Students’ Scientific Research Center, Exceptional Talents Development Center, Tehran University of Medical Sciences, Tehran 1416753955, Iran
Mehdi Karimi, Bogomolets National Medical University, Kyiv 01601, Ukraine
Vida Khalafi, Student Research Committee, Jahrom University of Medical Sciences, Jahrom 7413188941, Iran
Patrick Fazeli, Brown University, Providence, RI 02912, United States
Amir Human Hoveidaei, International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 21215, United States
Author contributions: All authors participated in the conception and primary drafting of the manuscript; Hoveidaei AH focused on conception and made critical revisions to the manuscript; Fazeli P contributed to the research as an individual consultant without using Brown University’s resources; All authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Amir Human Hoveidaei, MD, Research Fellow, International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, United States. hoveidaei.a.h@gmail.com
Received: June 29, 2024 Revised: July 31, 2024 Accepted: August 15, 2024 Published online: September 18, 2024 Processing time: 74 Days and 13 Hours
Abstract
Bone metastases (BM) are a common complication in advanced cancer patients, significantly contributing to morbidity and mortality due to their ability to cause pain, fractures, and spinal cord compression. Radiation therapy (RT) is vital in managing these complications by targeting metastatic lesions to ease pain, improve mobility, and reduce the risk of skeletal-related events such as fractures. Evidence supports the effectiveness of RT in pain relief, showing its ability to provide significant palliation and lessen the need for opioid painkillers, thereby enhancing the overall quality of life (QoL) for patients with BM. However, optimizing RT outcomes involves considerations such as the choice of radiation technique, dose fractionation schedules, and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin reactions. These factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor characteristics. This mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients, with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.
Core Tip: Radiation therapy (RT) significantly alleviates pain and improves quality of life in patients with bone metastases. Optimizing RT effectiveness involves personalized treatment approaches and supportive care measures to manage side effects, enhancing overall well-being and symptom control.
